From Transplant to Trailblazer: Mark Durante’s Exosome Breakthrough in Regenerative Medicine
Jun 23, 2025
WELCOME TO EPISODE 247
Nine years ago, Mark Durante received a heart transplant that saved his life—but it was just the beginning of his healing journey. When post-transplant neuropathy nearly disabled him, he turned to a friend in stem cell research. What happened next changed everything.
This episode dives deep into how exosomes work, what makes 3D manufacturing a breakthrough, and why regenerative medicine isn’t just for the rich and famous anymore. We compare exosomes to stem cells, explore cost and accessibility, and look at the growing global research. Whether you're a practitioner or just health-curious, this conversation might change the way you think about aging, healing, and what’s possible for the human body.
Episode Highlights
[01:10] – Mark’s heart transplant story and how post-op pain led to a regenerative medicine journey
[02:45] – Discovering exosomes through stem cell therapy and getting off neurological meds
[05:22] – The birth of Rise Up Medical and turning healing into purpose
[09:00] – Exosomes 101: what they are and why they matter
[11:30] – Stem cells vs exosomes: when and why they’re used
[16:00] – The 3D manufacturing breakthrough and why it changes everything
[22:30] – Use cases: from arthritis to anti-aging to advanced neurological support
[29:00] – What regenerative treatments cost—and why smart dosing matters
[34:40] – How to find a practitioner or get your doctor on board
[43:00] – Global studies, real results, and what's coming next in regenerative care
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FULL EPISODE INTERVIEW
EPISODE TRANSCRIPT
Freddie Kimmel (00:01.282)
Ladies and gentlemen, welcome to the beautifully broken podcast. We're here with our guest today, Mark Durante. Welcome to the show, Mark.
Mark (00:08.751)
Well, thank you so much, Freddie. I appreciate it, buddy.
Freddie Kimmel (00:11.81)
Glad to start the day talking about Exosome. So I'm not going to, we won't, we won't jump right in. I want to ask you a couple of questions first. Mark, what, what's the, what's like the purpose that, fills your sail to like keep you going to really like fire you out of bed in the morning.
Mark (00:19.759)
Sure.
Mark (00:28.101)
Yeah, well, you know, this company is a passion project. It's also what I would call legacy project because this was built out of a health issue that I had. what a lot of people don't realize is that I was a heart transplant patient from nine years ago and it came from an unknown cause. Nobody ever at the time, nobody discovered it. Later on, it found out that it was a genetic and epigenetic related issue where a gene was expressing abnormally and actually contributed to the cardiomyopathy.
However, I only discovered it due to a neurological issue. I was getting neuropathy that nobody could explain and later it was kind of related to the heart issue. But after I had the transplant, we thought that neuropathy would go away and instead it got worse to a point that it almost disabled me.
And it was at that point I was having kind of a desperate conversation with an orthopedic friend of mine who was in stem cell research and said, hey, look, I've got a pathway that I could take you down that I think could reverse it. And if it doesn't get you all the way, I think it's going to get you part of the way. So when I jumped into that journey, I wound up actually getting better, starting to come off of my medication. And then I hit this plateau. like anybody that's out there, once you start to feel the hope that comes from healing, then all of a sudden it's journey on, right? It is at that point.
Freddie Kimmel (01:40.579)
Yeah.
Mark (01:41.795)
started looking for solutions and I found a particular Acellular stem cell product that I utilized. It was being studied by a heart transplant cardiologist out of Cedars-Sinai. They were having amazing results so I started to use it myself and wound up reversing the majority of what I was dealing with. Got off a hundred percent of my medications from a neurological standpoint. I'm still gonna have to take heart transplant medications but from the neurological standpoint I haven't taken anything in three years and so at that point I just kind of this became not just my
own journey, but I thought I've been in medicine for 18 years at that point and I never even knew this was an option. And so if I don't know being in medicine, how does the public know? So I turned this into a journey to try and create awareness around these biologic applications and then created the portfolios around them to try and help our practitioners in the healing process. And from there, it's just become an innovative journey. And you know, you and I are talking about one of those innovations today. Yes.
Freddie Kimmel (02:38.686)
Unreal, I got goosebumps. I had no idea, Mark. I had no idea that you're sitting here and you're telling me you're walking around with somebody else's heart. That wasn't it. What an incredible, incredible story and experience. I can only imagine what that process is like for you.
Mark (02:55.729)
You know, I will say too, and a lot of people don't, you know, they don't recognize the pain that's involved. you know, I will say this, pain is a good thing. Because pain pushes change, right? And I remember sitting on the couch, talking to God and going, is this some sort of sick joke? Like you have me survive with a brand new heart to have me disabled with neuropathy.
so that I get to enjoy Netflix for the rest of my life. That's not the journey I looked for, right? And it was out of that that just, that pain started to create, you know, hey, I'm either going to be down and out for the rest of my life or I gotta find change. And it just started with asking questions that kind of led to a solution that ultimately turned into a business model.
Freddie Kimmel (03:21.912)
Nice.
Mark (03:38.193)
And now my life's journey is about trying to help others in that healing process. But we got to do it one practitioner at a time. And as you can see, this industry is growing quite immensely down the regenerative space. And so I just feel blessed to able to play a part in it.
Freddie Kimmel (03:44.654)
Mmm.
Freddie Kimmel (03:51.958)
Yeah, it's funny. There's, there's, I don't know if I told you this or not. I, you know, I was in the audience like, yes, Freddie, we know I used to sing and dance. So I did a Broadway music theater, you know, for, for 20 years. And in the middle of it was diagnosed with cancer and Lyme did all these crazy rigamarole, you know, and it was, it was, yes, pain created change. And I love to sing and dance, but I don't think somebody asked me yesterday, do you miss it? I was like, my God, are you kidding me?
Mark (03:59.897)
Yes.
Freddie Kimmel (04:19.352)
There's no people like show people. It's in a song for a reason. It's so fun. And it is like the nectar that makes life living worth it. And I don't think like, this is so important to me on a personal level to change the perception of what is available as far as like the facility for the human body, the mind, the spirit.
Mark (04:21.945)
Right. That's right.
Freddie Kimmel (04:45.006)
true health, which I never had until it was taken away. I never realized that that was a thing. And it's so important. I don't think I could set it down. I think I'm too passionate about it. I mean, I think I would be backstage reading articles and PubMed studies and trying to put together stacks. Yeah, it's just, it's really interesting to think about, be like, could I go back? I don't think I could.
Mark (04:54.725)
Correct. No.
Mark (05:08.281)
Yeah, no, no, no. As a matter of fact, I mean, that's the beautiful part of this passion, because I don't get the questions all the time going, Mark, are you a doctor? And I'm like, no, I'm just passionate. You know, I mean, when you go through this and you realize that there is opportunity that other people just don't know about, to your point, you're just looking for an opportunity to express a voice, to let people know there's hope. Because with hope, we can really accomplish anything, you know, so and that's that's kind of what this journey has been all about.
Freddie Kimmel (05:34.146)
Yeah, it's phenomenal spot to start. we're going to talk about like this. We'll put this in the sandbox of regenerative medicine and you know, the topic of the day, we're going to talk about exosomes. And honestly, we've had one deep dive on stem cells. We looked at the stem cell clinic that did Brian Johnson's procedure, who is this longevity guru who is just throwing millions and millions of dollars down to Bermuda and
really, really high end facility, not financially achievable for most people, you know, just, but awesome content and really, really interesting and a great setup and they need to be doing what they're doing, but we've never talked about exosomes. So let's just start. What is an exosome?
Mark (06:05.829)
Yes.
Mark (06:09.777)
Correct, Absolutely.
Mark (06:25.669)
Yeah, you know, it's in its simplest.
I guess definition, it's an envelope or a carrier molecule, or not a carrier molecule, but a carrier packet. The way we're using them in modern medicine is, know, exosomes right now, as we utilize them in with our practitioners, is they're carrying regenerative loads of proteins that are going to basically help heal. And in the simplest example, it's how cells communicate. So every cell type in your body has an exosome. It's how they kind of communicate with one another, drop off different, you know, packets
of information, allow them to heal, drop off regenerative molecules, helping the signaling process with the cells. And I mean, it's a complex story, but the reality is it's really a communication tool. But when you start getting into pharmacology, they're using that same structure, that lipid, to put...
You know, I mean, like we take a look at the vaccine, the code vaccine that was done in an exosome, right? They're putting an mRNA in there, helping it transport from cell to cell so that they can work with your, you know, your DNA in order to create the spike protein. However, you know, we're using it a little bit differently. These are naturally occurring in the body. And what we're doing is we're taking them from umbilical cord tissue, placental based tissue, and we're just trying to create abundance because at that stage of life, you're never going to have a more regenerative
mixture that could create the greatest change in the body. So what we want to do is take all those available proteins that could be very healing for the body, practice them up in these little exosomes, and then provide them to practitioners to use how they see fit to create change in someone else's body. I think the big thing that we want to state here is that the body has a very unique way of healing itself. just, it's very...
Mark (08:12.165)
I would call it nutrient or protein, it has a protein shortage, right? So as we age, we just naturally lose those capabilities and we lose, and it's a supplementation program. I think that's probably the easiest way to say it is that the same way you're taking vitamins as you get older to try and keep your vitamin levels high so your body can function at the most optimal rate.
That's what lot of practitioners are doing with exosomes. They're supplying back key ingredients to the body in a supplementation fashion because once the body grabs those exosomes, they can utilize them and start creating major repair.
Freddie Kimmel (08:45.4)
Yeah, so it's interesting. we just had, we had a longer foreign conversation around peptides with Dr. Adam a few weeks ago. Peptides are also a signaling molecule. So I'm hearing exosomes are there, there's a lipid layer, lipid enclosure, and then there's instructions inside for the body to repurpose proteins. And then we have other things we've talked about in the podcast and how to complement protein folding, you know? So how is an exosome different from a stem cell?
Mark (08:52.559)
Yes, they are.
Mark (09:11.289)
Yes, yes.
Mark (09:16.165)
Yeah, so exosomes are coming from the stem cell. So the stem cell kind of think of it as the major vehicle, the production unit. It's literally what is making the body. But the thing is is that inside that stem cell, there's a factory of things going on. And in doing that, once it creates all these various proteins that we're utilizing to heal the body, it packages them up in exosomes. And then those exosomes leave one stem cell to go to another.
Freddie Kimmel (09:42.67)
Mmm.
Mark (09:42.809)
they unpack that information so that that cell can now use that. I think that's the beauty of the...
When you talk about a lipid membrane, you know, this carrier envelope, basically it's something that is both, you know, it's the way to carry something, but it's also the way that the cell recognizes it's got certain receptors on there that basically allow it to be invited into the cell because not everything is given an invite into the cell. So you have to put it in a certain package that would be taken up by another cell so that it can unpack all those regenerative and signaling molecules in order to create either repair in that cell or just
go through certain processes that it can produce additional things that it will send off to other cells.
Freddie Kimmel (10:24.558)
And so when did we discover that an exosome was a viable therapy? When did it start?
Mark (10:31.441)
It was in the 1980s actually. As a matter of fact, in the very beginning, they actually thought that exosomes were just kind of like trash receptacles until they realized that that's how cells were communicating with one another. And once they discovered that in the 1980s, it kind of changed the way medicine looks. It's one of the reasons why pharmaceutical industries and various other biologic branches are using exosomes because it's how they get their particular material into a cell in order to create.
a specific protein, they need to do a job that is going to create the repair or reduce inflammation in the body. Yeah. Yeah.
Freddie Kimmel (11:06.222)
Yeah, fascinating. And so, you know, I started to do a little digging because this is something that I'm probably benchmarking the next 24 months. Is that I've never really done a big, I've done PRP, I've done a little, I did one exosome procedure, but it wasn't extensive. was kind of like, it was a little bit of a one-off. There wasn't a lot of like preparation or context. I didn't really know what I was doing.
Mark (11:16.966)
Right. Yeah.
Mark (11:30.896)
Yes.
Freddie Kimmel (11:31.192)
But in the next 24 months, I do want to commit to some of this regenerative medicine because, you know, I'm, what am I, I'm three years from 50. So I'm moving in that direction, right? And I'm realizing even the elite clean eating, the fasting, three times a week sauna, all the tech that I have at the house, we still age, right? Like, as you said, where these protein expressions and the coding, if you will,
Mark (11:41.903)
You
Mark (11:56.005)
that.
Freddie Kimmel (12:01.228)
becomes or the blueprint becomes a little less clear over time. like, I'm, I'm really interesting. I never felt like I could see myself aging. And I'm like, I'll go back and look for my picture three years ago. was like, wow, I was a baby. I can't believe there's like, you know, you is, isn't that interesting to watch that change over time?
Mark (12:17.089)
Yes.
No, it is. And you know, it's interesting because they did a study a little while ago, kind of talking, showing that progression because you almost can look at your quantity of stem cells as kind of the difference between life and death. Like you can almost track your progression through time because when they were looking at it, as they were looking at the amount of stem cells that were present in bone marrow at birth, and it was like one in every 10,000 cells was a stem cell. By the time you hit the age of 18, it was one in 100,000. So it had dropped off by tenfold by the time you're 18, the amount of
stem cells that were present. Now you have to realize this is the regenerative part of your body. By the time you hit the age of 30, it was about one in every 250,000 cells was a stem cell. By the time you were 50, it was one in 450,000. And then by the time you were 80, it was one in 2 million. But what people don't understand is that even as you're going through this loss, you're starting to get what they call stem cell exhaustion or start a stem cell dysfunction. So how do you improve what you have to help it in its replication process to help it in its
Freddie Kimmel (13:01.518)
Mmm.
Freddie Kimmel (13:07.064)
Mm.
Mark (13:20.819)
kind of getting it back up to 100 % is that's where we're starting to utilize things like exosomes and other stem cell or a cellular stem cell therapies is to basically supplement this back into the body. When the body has those raw materials, it knows exactly what to do with it in order to create change. And honestly, with a lot of these stem cells being, you know, lacking in the body, there's nothing to help control a lot of inflammation and breakdown. I mean, you're just putting a single cell on a major workload.
Like none of us could just work to an exhausted fashion, but that's what our stem cells are doing in our body. So at this point, we just need to kind of give it the raw ingredients that it needs to help it function at 100%. And then we start to kind of see that. I think that's where you get, here at most age management, but that's where you have that kind of anti-aging word pops up because truly,
And a lot of the work that they're doing around the world, they're seeing a reversal in the biological age of a patient. So you kind of have like, hey, this is my human age and then this is my biological age. And they're showing that given the right supplementation, they can start to reverse the aging process. And next is the key part.
Freddie Kimmel (14:27.64)
Yeah. Now, before we get into your company, again, I want to just, for the audience and for my brain, can you compare? Is it like comparing apples to apples when you're saying, well, I'm looking at a regenerative procedure here and I might go with an exosome, I might go with a stem cell? Is that fair to do or not really?
Mark (14:52.759)
No, it's I mean they are apples and oranges, you know, we think that's where it's up to the practitioner to make the decision what fits correctly, know exosomes a lot of times when we look at this we look at them for more preventative measures for aesthetic measures for more acute type cases But when you're starting to get into more chronic and long-term cases You're going to have to give such a mass dosing of exosomes that oftentimes either a combination therapy with exosomes or doing some sort of a cellular or stem
Freddie Kimmel (14:55.447)
Yeah.
Mark (15:22.673)
self-therapy becomes kind of the right choice. So it really is in your degree of degrade, I guess is the best way to put it.
Freddie Kimmel (15:30.008)
Yeah, yeah, so interesting. Now, if you do look at them, there are different, you know, I did a little research over the last two weeks before we had this, and there are really interesting, it looks like the safety profile from my research is much higher on an exosome. And like you're saying, like if something is really serious, then your heavy hitter, it's possible that it could be a stem cell procedure.
Mark (15:56.879)
Yeah, so when you look at this too, and I think what a lot of people are relating it to is that when you have a whole cell, you have receptors on there that basically could cause an immune reaction when you transfer them. To be fair, it is so minute of that happening when you're using the correct type of stem cell, like something from an umbilical cord or placental-based tissue. And people oftentimes recognize this and where the immune reacts. It's one of the reasons why when you're older, you can't just give your stem cell to someone else because it's kind
It's specified at that point. Basically, the way I always kind of describe these stem cells is that it was when we were in high school and we were out there for gym class and we were being picked for a team, we're all lined up and then there's two team captains. Well, all of us lined up out there.
We haven't been specified yet. We're not on a team. But then we'll call it team bone and team skin is that as you start getting chosen, now you've specified. Well, once you're on that team, you can't be another team member. it's kind of like, can't, know, once I've become my bone, I can't mix with your bone. But when we're working in umbilical cord tissue or we're working in placental base tissue, it hasn't been specified yet. So at that point, there's not the same receptors that could actually trigger the immune response. Now, a lot of the reasons why
Freddie Kimmel (16:45.123)
Hmm.
Freddie Kimmel (16:55.939)
Yeah.
Freddie Kimmel (17:00.526)
Hmm.
Mark (17:12.519)
of people like exosomes sometimes over stem cells too is because they worry about DNA transfer. I just don't think that that's something that's playing like a major role. Again, it's a non-specified target at this point. But look, you got to be comfortable with where you're at. So when we work with a lot of things, we're working in what we call acellular products. And right now, a lot of people going for stem cell therapies are going abroad where...
Freddie Kimmel (17:17.646)
Mm-hmm.
Freddie Kimmel (17:25.111)
Yeah.
Mark (17:37.647)
you have those capabilities to do in mass. And in an Acellular, you're either taking the cargo from the stem cell, but you're not taking the whole stem cell. And then you're reintroducing to that body as a supplement, supplementation program.
Freddie Kimmel (17:46.798)
Mm-hmm.
Freddie Kimmel (17:51.03)
Yeah, yeah, fascinating, fascinating. I, yeah, yeah. So with all that said, comparing exosome system cells, you also, have a, you have a gen two of an exosome that you're working with through your company. So I kind of want to learn about that as well.
Mark (17:53.605)
Yeah, they're exercise the way they're doing it.
Mark (18:12.229)
Yeah, so it's a way it's manufactured. So it's a 3D based exosome versus 2D. And what the 2D versus 3D is really describing is kind of the environment that those exosomes are put in. So when you look at today, most of us, until we came out with the 3D version, we're all manufacturing in a 2D. And the best description that I give people between a 2D manufacturing of exosomes and a 3D manufacturing is think of 2D like being grown in a petri dish. It's kind of being grown
in a horizontal fashion. When you look at 3D exosomes, they're grown like you're growing grapes on a grapevine. So it is fully exposed to the entire environment so that it can pull nutrition from the roots, it can pull the nutrition coming from sunlight, where you can kind of look at it going 2D would be like an apple that fell off the tree and hit the ground. What happens is it's not gaining the same nutritional value any longer. And part of it is sitting on the ground where it's having no value whatsoever.
Freddie Kimmel (19:04.526)
Mm-hmm.
Freddie Kimmel (19:12.024)
Yeah.
Mark (19:12.083)
As you're being exposed to the environment out there, you're not getting the full benefits. And so what we're doing is though 2D has been a fantastic measure, we've come to realize that one, we can produce more proteins per exosome to give that greater boost. But because that exosome mimics the way it's naturally grown in the body, there is a better uptake of that exosome into the cell that is being utilized in. And so we see about a 30 % better uptake.
that I look at and if you just kind of want to understand why a body would choose a 3D over a 2D is think about going to the grocery store and you want to pick out a piece of fruit. If you see a bad spot on there you're gonna put that that apple back down but if you see one that is beautiful shiny you know perfect that's the one you're gonna take home and that's your cells look at that the same way so as these exosomes are floating through it's it's picking its fruit.
And so what we see is because of the way the 3D has grown and how in a more perfected model it is, there's a better uptake. So now there's a better usage.
Freddie Kimmel (20:14.86)
Yeah, are the, good, how did this application start? Did you guys come up with this or is this an innovation in the last two or three years?
Mark (20:23.653)
No, no, as a of fact, the innovation has been around for a little bit, but what happens is you have to invest in major technology in order to kind of create this new 3D environment. So a lot of companies are just going, hey,
We're getting results with our 2D, we're happy with where we're at, and they just keep pushing the 2D model. For us, and again, like I say, because this is a passion project of ours, we're looking worldwide at the research that's being done, and then we're trying to incorporate the latest and greatest type of things because, and I'm not saying anybody else isn't doing this, but as our passion project, we're not only trying to scale to make it affordable for everybody, but we're trying to produce faster, better results. And we know we can do that with 3D, so we made the investment in order to bring 3D exosomes to the country.
Freddie Kimmel (21:05.059)
And what is some of the research that compelled you to say, my God, we got to look at this?
Mark (21:09.485)
A lot of it's been worldwide research. know, some of our labs actually have a worldwide presence and so they're doing a lot of research outside the United States and 3D has been around there for a little bit. So we've been able to take a look at some of the work that they've been doing with inflammatory cases, with wound care. There's been some research that's been done around kidney repair. There's been a lot done in 3D exosomes, even in cancer research. And though we don't deal on the cancer side of the research of things, the reality is is these 3D
3D exosomes are being widely contributed to better results in these type of products. Also, when you're getting into more genetic research where you're kind of getting involved in the gene activity, they're using 3D exosomes because they need these cells to be better absorbed so that that gene therapy works. so even though we're working it from more of an umbilical cord and placental basis in your traditional regenerative model, worldwide they're starting to be utilized in a variety of other therapies.
Freddie Kimmel (21:52.238)
Mm-hmm.
Mark (22:09.105)
they're gonna they're gonna play a major role in the future for reversal a lot of disease states. Yeah.
Freddie Kimmel (22:14.36)
Fascinating, fascinating. So when somebody's considering a procedure like this, like who do they go to? What does this look like?
Mark (22:22.993)
Yeah, you know, as a matter of fact, I mean, it's... You're going to go to your practitioner for sure, you know, but the thing that... Yeah, exactly. And I say that because it's like, you know, no gray markets, you know, it is... If somebody invites you to their home in order to get exosome therapy, maybe you should say no, but it is... But when I say this is that I say that kind of broadly because today, regenerative medicine...
Freddie Kimmel (22:29.25)
Yeah. You're not going to pick these up in Whole Foods and self-inject or the vitamin shop.
Mark (22:50.065)
kind of ranges. I have plastic surgeons that are fitting into regenerative medicine, dermatologists fitting into regenerative, family practice, OBGYN. So it's kind of like, I'd like to tell you that there's a specific person that we target. But I think what's happening is you just get a field of physicians that are saying, I'm either tired with traditional medicine, I see where this is going, I want to be a part of the future of this. And they start jumping in. And there's plenty of research. mean, here's the here's the reality of it. Last year, just on PubMed, there were 25,000 studies.
that were being done around biologics. So if somebody comes and tells you that they're not researched enough, it's because they just haven't been going out there and researching. Because the year before, there was like 22,000 studies that showed up in PubMed. That was PubMed alone. And you've got Nature, and you've got Cell, and all these different journals that are bringing forth all these studies. This is all around the regenerative aspects of what we can do next. So when you're looking at that, I just think that you want to try and connect with a practitioner who is
Freddie Kimmel (23:27.854)
Mm-hmm.
Mark (23:49.527)
open-minded to the possibility that we can literally use the body to heal the body. is, and I'm not an anti-surgery and I'm not an anti-pharmaceutical because I tell everybody I had to have a heart transplant. I needed a surgeon. I've had back surgery. I needed a surgeon. I can't live without certain medications, but I think what we're looking at regenerative medicine as a first line defense before having to go to pharmaceutical or before having to go to surgery. And if people become aware of it early on,
Freddie Kimmel (24:02.21)
Yeah.
Mark (24:17.285)
they can prevent a lot of those things from happening or they can delay them far off into the future. And that's what the ultimate goal is. So I think really it's kind of coming to the open-minded practitioner who is becoming well-studied in that. And then you just kind of have to dig down and kind of understand what are you doing? I remember the purple pill. When the purple pill first came on and they didn't tell you what it was for, they just said, talk to your doctor about the purple pill. I think that's kind of the same way that we're looking at regenerative medicine. We're going.
Freddie Kimmel (24:40.078)
Yeah.
Mark (24:43.665)
Talk to your doctor about 3D exosomes. Are they doing it? If they're not, ask them why and like try and get them connected. You know, because medicine has progressed and we're just trying to be on the forefront of that progression.
Freddie Kimmel (24:55.072)
Yeah, yeah, it's yeah, I would join with you there. I also think there's like, you know, this is not something you're going to go to your your your GP for, you know, this is a this is generally, you know, it's it's a functional medicine. It's a regenerative medical clinic. It's a biological medicine clinic.
Mark (25:13.617)
Correct, correct. And in fairness to a lot of those functional medicine doctors, we're family practitioners that just decided to elevate their learning into the functional side. And so you're correct because functional medicine practitioners look at the body and look at the lab results differently. It's a little bit more expansive. So I think medicine has given us kind of general guideline, functional medicine is going, okay, there's so much more to this complex body we have.
Freddie Kimmel (25:19.512)
That's right.
Mark (25:41.745)
I think we're gonna have to take a little bit more. And I think too functional medicine looks at it going, what did your lab work look like when it was in its 20s? We don't wanna accept the way it looks in its 50s. And it's like as time progresses, people just go, well, this is what you're supposed to have because you're just older. Well, no, actually I don't. I can actually reverse my body to mimic more of my 20s. And at that point, I want my lab work to look like I was in my 20s, not like it is in my 50s.
Freddie Kimmel (25:52.056)
Yeah.
Freddie Kimmel (26:08.94)
Yeah, it's, it's right there with you. The, you know, the, the, the question I have is when people are, you know, looking at these procedures or, know, they want, they, they want, we want, I want to go mountain biker and I want to, I want to be able to go to Yellowstone and I want to do 20 miles of hiking. And I know like my knees or my hips or, you know, some looking at these regenerative therapies.
What are people looking at as far as, and I know it, Matt, know every single body is different, right? The weight of a person, the age, your biological age, how you respond to a therapy, but can we talk about price a little bit and investment from a consumer standpoint? I know the, was actually, I looked it up, the company that we had on, was Cell Collabs. You know, I want to say their base price was 27K to go to.
Mark (26:46.257)
Yeah.
Freddie Kimmel (26:59.426)
Bermuda and be involved in this case study and really get a high end procedure. What are people looking at? And maybe we can take an example, Mark. Maybe we can do something like, somebody with arthritis in their knees. You know, they want to do a course of exosomes. What are they looking at as far as an investment and how much of a time commitment for that treatment to be executed and then have a response possibly?
Mark (27:12.677)
Mm-hmm.
Mark (27:24.633)
Absolutely. mean, here's the thing too, with exosomes or any other other Acellular type of products that are not the full stem cell, they can range and it's all based on, but let's just say it could be anywhere from, you know, three or $4,000 to it could be six or $7,000. It is, you know, I honestly tell people is the challenge that I'm seeing with the industry right now is a lot of times we see that and it's a
There's not enough education out there. So a lot of times people think one exosome is the same as another. And so the practitioner will a lot of times base it on price.
And it's just not the case. The thing is that, you know, as everybody's hiding their secret sauce, it's hard for a practitioner to understand what the true difference is. It's one of the reasons why we're trying to bring forward the 3D exosomes, because we're really trying to say, there's mass differences and we can show that just in study data, why you'd want to make a leap to a 3D over a 2D exosome. You know, in doing something like that, you know, could we make it more economical for a patient? Hey, look, if you can get...
three to four times better result going to a 3D exosome over a 2D exosome, then yes, you're not gonna come back a second time. The challenge is if you underdose somebody, you're coming back multiple times. that's the crazy story that I'm trying to get through right now because when our practitioners are doing it, we're trying to tell them, it right the first time so that you don't have to come back. It's gonna look more expensive. But a lot of times too, we oftentimes sell to our patients the same way we would
Freddie Kimmel (28:44.44)
Hmm.
Mark (29:02.663)
buy. So if we don't have the faith in it yet that it's going to create change, then a lot of times we'll sell a cheaper product just to say, Hey, you're getting regenerative medicine. Your pain's going away. But at the end of the day, the repair didn't really happen because exosomes manage inflammation and repair. And a lot of times if you don't put the right exosome in place, you may address the inflammation, but you may not fully address the repair. So dosing is critical for a lot of these practitioners. so it is, and then giving them the right type of exosome because
exosomes come in all kinds of wild flavors, right? I mean, it's kind of like chewing gum sometimes. You can have grape, strawberry, or lemon. What's your favorite flavor? So I think at that point, you're trying to narrow it down and going, hey, I have to line this exosome up with a joint-related issue, or I have to line this up with a hair-related issue, or I have to line this up with a skin-related issue, and vice versa. And I think what the studies are also demonstrating too is that giving the right dosage,
Countries worldwide are seeing a reversal in all kinds of things. And you can look to the studies to find that data. I try to stick my head in there all the time because sometimes I even look at it and go, hey, maybe we're still underdosing. Like if we did just this much more, it would get the job done. So it's kind of a long way around getting you to the answer of how much is it and what does it look like. But I could say it could be thousands of dollars to address an issue. could be, I will say it's probably 50 % of what you would have to pay to go
abroad. It might be a better example and it's really up to the practitioner and how they decide what product and what dosing in order to provide.
Freddie Kimmel (30:37.858)
Yeah, that I mean, that's kind of what I saw and what even again, it was like, it looked like half to a quarter of the price, depending on, you know, depending on what you're going after and what your age is. And, you know, it's, really, I know it's a shitty question to ask. Well, let's compare apples to apples because we've already said it's not that game. And I just like to frame it for people. It's like, well, you know, is this something that I need to
Mark (30:45.357)
Okay, it is.
Freddie Kimmel (31:04.75)
explore. I want to say that too, because we have so many, we have so many consumers that listen to the show, but then we have, we definitely have a fair amount of practitioners. And I just, I think this is a call out to a practitioner, like where do they go to learn about 3d exosomes? Where are people going to do the research and the training and education mark to learn if they decided they were interested in the science that this is definitely something they want to apply in the clinic.
Mark (31:30.949)
Well, and I would say this, there's very few people that are really involved in 3D exosomes. So lot of it is going to, if they came to our company, which is RiseUpMedical.com,
There you can go to one of our pages to learn about 3D exosomes. A lot of those practitioners, once we jump on calls, we can provide them with the research that actually shows them what's occurring. The understanding is that it's a worldwide research that's occurring. We're just trying to bring worldwide here to the United States, right? Because it is, and then we're trying to work very closely with the FDA in order to try and get these things passed through. nothing has been, I think it's very important to state here now, in the exosome-based world, nothing has been FDA approved for certain indications. So it's really the practitioner
is utilizing this as a tool, but just know that companies like ours are in the background trying to get these through the FDA so that we get specific indications that make it even more available. Because when we get those approvals, scalability goes through the roof, affordability becomes more accessible to all patients. And that's the ultimate goal. And just, you know, I want people to know we're in, we're still in the very beginning and earlier stages, but we're at the right time because practitioners, you know, consumers, they're all learning this together. And
Freddie Kimmel (32:26.55)
Yes, man, be awesome.
Mark (32:41.287)
I think it's in a joint effort that we're really pushing this and the FDA and all these different regulatory bodies see the benefits. They just wanna make sure it's safe for the public, right? And so, and that's the other thing too, that we have to work on these safety profiles. the FDA may hold us back in a lot of cases, but they're also good because anytime you get a good thing, you also get the bad, right? So in this space, we're grateful for all things.
Freddie Kimmel (33:08.674)
Yeah. And just loop in how, like, let's say a practitioner is on board, they're really stoked about this. Where did they learn to execute? Where's the training? How did they learn dosing?
Mark (33:19.119)
Yeah, so dosing is not something that we can actually, a lot of them have to look into the study data in order to see what the dosing guidelines were like that from, you know, in the studies. It because that's the practice of medicine and that's the challenge. I think the key thing is that when we look at it, most people just think that dosing is standard for everybody. And you and I talked about this before a six foot four male and a five foot two female shouldn't be dosed the same. So I think they've got to look at it. It could be body weight. It could be height.
Freddie Kimmel (33:24.28)
Mm-hmm.
Mark (33:48.995)
It could be, mean, there's a cellular difference between those two individuals. And so in doing so, I think that's where your practitioner has to really kind of take a look at the condition and then also understanding where's the severity of the condition? Is it something that you just discovered or is it something that you've been dealing with for the last five or six years? And then once they figure that out, there's plenty of research being done that can share with them what that looks like. And like I said, we can always help point them in the direction of where that type of
research is and then they can come to their own conclusions.
Freddie Kimmel (34:21.41)
Yeah, like if my esthetician in Austin, Texas alchemy beauty, she's already using exosomes for her aesthetics. She's going to have dosing profiles that she's she's as a trained nurse practitioner and esthetician she's she's already queued in so she's going to know and she's she's basically saying she's like, this looks really interesting sounds like an upgrade to what I'm currently using in my arsenal or my toolbox. This is a conversation I want to have.
Mark (34:28.4)
Yes.
Mark (34:33.659)
That's correct.
That's correct.
Mark (34:47.781)
And then think it's a learning experience too. A lot of times too, you talked about PRP earlier and a lot of them have realized that, most of our regenerative aspects were done with PRP. So they understood what dosing looked like there, right? But they were like, but it was showing up short in a lot of areas. And then all of a sudden you realize it's missing a lot of these key proteins that are playing a repair. So now you bring in exosomes that have 20, 40, 50, 50 times more of these key ingredients to create repair. And so they go.
Well, you know what, let me kind of start with a smaller dose, see what happens. And then if it doesn't get enough, then we kind of move up and move up. And it's really a process of trial and error, right? And it's, think that we have enough practitioners that have gone through the trial and error where they have their own kind of dosing calculators. And that's one of reasons why you have to really kind of talk to them. But we're just trying to really fine tune it. I guess it's the best way to say it is going, hey, further research is coming out showing that you should do this. Like I think there was a study that was done in Japan where they were
Freddie Kimmel (35:38.318)
Mm-hmm.
Mark (35:45.123)
talking about like Alzheimer's and that Japan had come out and said, hey, I think we've got the cure for Alzheimer's and dementia related issues. But when you looked into that study and you saw the amount of concentrations that they used, it's to your point, you could never afford it here in the United States. But.
they did, they found a dosing that worked for them that they were claiming could be a curative dosage, right? So then I think practitioners look at what the research is being done abroad and then come back and go, and okay, well, what can I do to start this? know, it is, do we start a journey? Do one day we get it to affordability where we can give those types of doses that are necessary? I think that anything that you're, you know, you're doing right now that's supplementing the body, it'd be like telling somebody, if you take vitamin C,
going to feel better. I think we'd all agree that that's true, right? It is, there's going to be some sort of health element. So I think when you're doing exosomes and these different therapies that practitioners are coming forth, they're getting some form of good, whether it's playing a role in prevention or it's actually starting to bring relief from what they're dealing with. And then your practitioner can then dose along with you based on what they see as needed next. So sometimes it's a multi-treatment approach, right?
Freddie Kimmel (36:57.592)
Yeah.
Yeah, 100%. And I noticed on your website, you have things like PRP kits and centrifuge machines. Like you have all the tools for people to be able to order and get going on some of these other very like, you know, you want to talk about a cheap treatment, like pull your own blood.
Mark (37:04.838)
Correct.
Mark (37:16.379)
Correct, correct, correct. And you know, part of it too is that we try to meet practitioners where they're at as well. You know, hey, look, if you're PRP bound, then we want to be there producing the best PRP with you, you know, but a lot of them now are using PRP in combination. So they're just kind of like going, hey, we're going to do some PRP. We're also going to do some exosomes and we're going to create this synergistic approach between them all. And so we're really trying to help them develop their own protocols that could advance medicine because combination therapy is key. You know, to say that our exosome is going to be the only thing that you're ever
going to need in order to repair, I'd be lying to you. So it is one tool in the toolbox and maybe it is your gift, but for others they might need a combination of things. So we're trying to give as many tools to the practitioner to get the job done.
Freddie Kimmel (38:00.374)
Yeah, yeah. So we said earlier that Exosomes are kind of like there's different flavors of chewing gum and there's tons of stuff. Can you explain that to me? And just we can speak specifically to Rise Up Medical. And so you guys have a really, now I'm not a medical doctor. So I'm looking at it I'm like, my goodness, what do I pick? What are all these different options and what's the value proposition? So maybe we can take two or three products that you guys offer and we can explain the points of differentiation.
Mark (38:30.063)
Yeah, so I actually have a perfect example right now of what we're doing because, you know, it is in the general exosomes that we're deriving from umbilical cord, I would call that kind of like your general overall wellness exosome. It literally gets the job done for a lot of things. But what we're doing now in the research is getting more specialized. So to kind of give you an example, in the past, we would use Wharton's jelly or umbilical cord exosomes to treat hair.
Well, what we realized is that that was playing a role on the microenvironment around the hair follicle. So when I say microenvironment, like look at a hair follicle as kind of the plant, think of the microenvironment as the soil, and then think of the roots, the physical blood flow to it as the root system supplying nutrition to it. One of the things that we just recently brought forth, and you'll see it on our website coming up here in about the next week, is a new program we call Boost Your Roots. The reason why we created it is because we're working with practitioners
to use both the Wharton's Jelly based exosome to improve the soil, but that we just came up with a very specific exosome called a dermal papilla exosome. Dermal papilla is the command center of hair follicle growth. And all it's job is to do is just to affect how that hair grows while the micro environment around it is basically supporting it so that it doesn't have any resistance points. Kind of like it's clearing the path for a healthy hair. So now we're getting very specialized. And that's why I talk about flavors is that, you
We're going to get some that could be cardiac related, some that could be neurologically related, some that could be hair follicle related. These are all in development and in the works because it's how we're feeding them, a particular protein set that's going to play a key role in that change.
I would just say there's a lot of background research that's going on that is going to change the way we do things in the future. And like the dermal papilla is just one of them that we're bringing forward. Making that move from 2D to 3D could be a whole nother flavor, right? Because it's just, it's taking what we used to have and just making it that much better. ultimately we're trying to create as many flavors because we realize treating everything as a general case isn't always going to be the best way. So then how do we get more specific so that we can produce
Mark (40:45.521)
better faster results. And so that's a direction we're going with the chewing gum flavors.
Freddie Kimmel (40:50.638)
Do you have any either anecdotal or experiences with clinics that are using some of the exosomes for chronic illness like Lyme disease, fibromyalgia, chronic inflammatory response syndrome?
Mark (41:04.144)
Well, I mean, and here's the thing is I do know a lot of cases because, you know, practitioners are trying them for a variety of things because they're dealing with them in inflammatory related issues. know, exosomes are very anti-inflammatory. I mean, they've got anti-inflammatory properties. And a lot of times when we've seen this, even in some of the research that we did early on when we were using exosome based products or a cellular products, one of our studies that's published was actually in COVID-19. We were taking patients that were in the hospital
that were in ICU and we literally did a double-blinded placebo-based study, meaning that the person receiving it had no clue what they were getting. One of them got, half of them got placebo, which could be a sugar pill. The other one got the Acellular Stem Cell product, right? It is when the study was finished, the group that got the placebo, there was a 47 % death rate.
In the group that got the Acellular Stem Cell product, there was a 7 % death rate. And when we look at this, though, we didn't go deeper into the study of why that was. Some of what was suspected is that we always heard about the cytokine storm that was happening during COVID. And that was what was taking a lot of people out. The body was getting overactive. Its immune system was getting overactive. And the body couldn't repair itself. It was staying in a continuous inflammatory state. So what we suspected was that these proteins were playing a role to rebalance the immune system so that
that it could get to balance and then start to repair itself with the other proteins. And so these are some of the things that were as an anecdotal type of conversation. That was physically in a study that we saw some phenomenal results with.
It we see this being used in sexual health. We see it used in hair restoration and part of it too. When you look at sexual health, people always think that it's, you know, hey, it's just the treatment of the penis or the vagina. And it's like, no, you have to realize this is a cardiovascular. This is a neurological issue that's there at the same time. So a lot of practitioners are saying, hey, I'm not just treating the area. I'm going to treat the body as a whole so that basically the entire support system comes and works functional. Of course, we know there's hormone imbalances and stuff as well, but
Mark (43:12.915)
from an exosome or a cellular stem cell. That was actually one of our other studies was in sexual health. we see a lot of different cases. We've seen practitioners using it for Alzheimer's and dementia because exosomes...
they can cross the blood brain barrier and they're using them in different fashions just worldwide they're using them. If you went to Mexico or you went to Panama or you went, they're using a lot of these products because stem cells as a whole are very large molecules, are very large cell structures. They can't pass the blood brain barrier where they need to function on the central nervous system, but exosomes can. So there's a lot of different applications that this is being utilized.
Freddie Kimmel (43:53.688)
Yeah. How many clinics do you have in the US that are currently using the 3D exosomes? Okay.
Mark (44:00.507)
I'd say hundreds right now. is something that is continuously expanding. We're seeing probably the greatest ramp up now of ever before because...
you know, even now when we created the new biological filler to kind of take the place of traditional fillers. It's a new area, but a lot of practitioners are using exosomes with that biological filler to, again, improve the overall environment of the skin. it is, there's a lot of cool things where exosomes on their own do one thing, but in combination play a whole nother role and amplify the effects of everything we do.
Freddie Kimmel (44:33.847)
Yeah, that's another area where I just say, you know, if anybody's doing fillers right now and they're synthetic, you know, a lot of times those things don't leave the body. This is one thing that my esthetician here in Austin is, you know, it's PRP, it's exosomes, it's biological tissue, as opposed to something synthetic, which after 10, 15, 20 years, we really, I mean, I say we don't know, but then we all have seen those pictures of people.
in the movie industry and like, my God, what are you doing? I actually shared a story yesterday on my Instagram stories of some clinic who is doing, they're changing the color of people's eyes. They're like, Carl really wanted his Azul blue. And I was like, Carl, there's some other stuff going on. You know, it was just not, it was like, no, stop. Anyways.
Mark (45:01.019)
Correct. Correct.
Mark (45:13.059)
Yes.
Mark (45:19.365)
Correct. Yes, yes, no, no, no. I mean, it's very true. And I mean, as you see this, there's a real thing called skin fatigue that's happening from the traditional filler.
And so when you're doing that, have to realize synthetic fillers are just creating volume. They're just trying to take up space that once was there, but it isn't any longer. When we're trying to do these biological fillers where we're utilizing this with, you know, PRP and exosomes and converting these things into different, you know, into different uses, the it is basically rebuilding what was lost. You you have fat loss, you have bone loss, you have skin loss. And so if we're doing this all correctly, a lot of these will play, you know, each product will play a different role in the tissue. But the ultimate goal is
Freddie Kimmel (45:36.899)
Yeah.
Freddie Kimmel (45:55.138)
Yeah.
Mark (46:02.431)
How do we store you to look more like your natural youth? And honestly, we just have to give back to it all the resources that it had that made it youthful. And that's honestly what exosome PRP, know, Acellular Therapy is all about.
Freddie Kimmel (46:14.112)
Yeah. Yeah. And it's also, you know, I think I always, I've thought it's crazy or a missed opportunity that these clinics, cause there's, think somebody told me that in Austin, Texas, there are, there are, there were thousands of clinics that were in the aesthetics and thousands just doing Botox. That's the only thing they do. And they were like, it's like the, it's the quickest startup. It's the, it's a huge markup on it. Yada, yada, yada.
Mark (46:41.809)
Yes.
Freddie Kimmel (46:42.062)
And I've always thought it was a huge missed opportunity. It was like, why don't these people pair with some type of a systemic treatment like a full body infusion exosome and like be connected to a gym? Cause you can't just throw paint on an old Volkswagen bug, right? It's sick. It's the rust is underneath. Like you got to change the musculature and the posture at the very least, like a gym and a nutritional profile and.
Mark (46:55.345)
Right.
Correct, correct, correct.
Freddie Kimmel (47:08.238)
Do a sleep hygiene commitment. Like I'm going to commit to whatever my sleep hygiene protocol is for the next 60 days. Like people will, you'll look different from that. You look less ragged.
Mark (47:09.029)
Yeah!
Mark (47:19.441)
Well, and you know, and you saw it because you had your other guest on there was talking about peptides because we deal in peptides as well. And that's a perfect example because peptides really gained a lot of popularity amongst athletes in the gym. So if you want to kind of see is they're just kind of going, hey, my body needs certain resources in order to be able to accomplish what I'm accomplishing and stay at my highest performance. And peptides gained a great, you know, a great lunch. it's to your point, all these other products of these practitioners aligned with them.
there's areas peptides don't serve. I always tell everybody peptides kind of play a supplemental take home program that keeps the body in a heightened form of reducing inflammation and repair. But I've had cases where I've used peptides in order to basically help take the pain and stuff out of my shoulder, but still had to actually go have biologics put in there so that it could do a repair of key areas, ligaments and tendons and cartilage in my shoulders.
Freddie Kimmel (48:16.184)
Yeah, yeah, it's fascinating. Well, Mark, I wanna close it up here. I think this is a really good starting point. I do wanna say like the call to action for practitioners to learn more about rise, learn more about 3D exosomes. Where are we telling people to go?
Mark (48:21.989)
Yes.
Mark (48:35.759)
Yeah, if they want to go to www.riseupmedical.com, they can do that. They can also contact us directly at 469-269-0844. know, people are also, if they connect through there, a lot of them will get connected directly to myself. They want to have a little bit of a deeper conversation, but we have a full team of people, you know, that are helping to bring this to you because I really call ourselves an education company first. And it just so happens that we've got a portfolio of products and go along with that education, you know, because that's what we
have to do to change the world.
Freddie Kimmel (49:07.31)
100%. And you know, the other thing I just want to ask like, let's say I am a consumer, like, how do I get my and I'm really interested in this, how do I start to get my doctor on board here? Is this somewhere where you know, I'm imagining you probably have patients advocate for some of these therapies being brought into the practice.
Mark (49:31.057)
We do and as a matter of fact not every practitioner is ready, right? So a lot of times we create a network of practitioners that if your practitioners are ready We have others that are that could basically we could connect them to so that they could Get some exposure to this because it really does like I say it's the purple pill like Consumers have no idea the strength that they have in order to create change in the market and honestly we need them more than anything because When enough questions are asked the practitioner and it's not the fault of the practitioner I have to say that very much like so much
information is being flown at them and them just trying to manage a practice. A lot of times they're listening to the patient and when they hear enough they dig and go there might be something here let me go research this and next thing you know a lot of those practitioners suddenly jump into the functional regenerative medicine side change their practice change their patients forever you know so a lot of it is just creating exposure.
Freddie Kimmel (50:19.149)
Hmm.
Yeah, 100%. I think every practitioner I've ended up calling some new company and I'm like, you got to get this tack or this equipment or this device does this and you got to get it in there. And you know, I bug and bug and bug enough times and eventually like, okay, okay, okay, okay.
Mark (50:31.995)
Correct. Correct.
Mark (50:40.303)
And that's it because literally like when you go to a question asked is a question answered. It's just who you ask in the question to. You know, so yeah.
Freddie Kimmel (50:46.698)
Yeah, that's great. That's great. I love it, Mark. Well, super, super high level information. I'm stoked to, again, in the next 24 months, it's definitely going to be something I invest in. And really, really excited to just get this ball rolling on the podcast.
Mark (51:00.454)
man.
I'm grateful to you because you're the voice, right? And so it is, you know, I'm just grateful that you brought me in here because now it gives us an opportunity to give exposure and start those conversations. So I appreciate you, Freddie.
Freddie Kimmel (51:16.014)
Yeah. Yeah. So we have our call to action step, you know, we're going to keep moving the needle forward and bringing on guests like this. Mark, thank you for just what you're doing. Incredible story that you're sitting here with a new heart anyway. Like unbelievable, unbelievable. Can I ask, can I ask you a couple of questions before we go? Tell me what, as somebody who's received a heart transplant, you mentioned having back surgery and you got a good janky shoulder. What's your, what's your
Mark (51:27.523)
Yes, yes.
Mark (51:42.308)
Yes.
Freddie Kimmel (51:44.8)
Exosome life look like is this something that you use in your treatment?
Mark (51:49.105)
Oh, I do. As a matter of fact, I have practitioners that I go to that I consider them my regenerative specialist that, you know, I will tell you, I've had like I had knee issues where I couldn't walk upstairs for for I mean, literally, I was in severe pain and I'm now almost three years later with zero knee pain. So I have to do in a single treatment on one knee and two treatments on another. It is I just literally did a repair in my shoulder. You know, I did something while I was working out and it's been bugging me for months and I literally
literally just went in and did my shoulder. I've done my back. I've done, I've even done intrathecal injections, which is spinal fluid in order to try and help with my overall central nervous system and memory care. I mean, there's, I have done, I have utilized my body for science, Freddie. I've done these in every angle. the answer, and you know, and here's the important part about it too, and it brings to the safety characteristics of this.
Freddie Kimmel (52:35.587)
Great.
Freddie Kimmel (52:42.435)
Yeah.
Mark (52:43.043)
I'm on immune suppressing drugs and so I have to be very cautious what I put in my body. And so we don't bring anything into our company that I can't use for myself. So that's why a lot of times I do use my body for science. It's a confidence booster.
Freddie Kimmel (52:55.18)
Yeah, I think the safety profile for me is huge. I think the idea of the cost for an exosome treatment brings it into a realm of reality, at least for most people, because we're talking about the price of a very small car for a stem cell procedure. I think the, again, when we're talking about the ease of use, for me, I'm hearing, well, if I'm already doing PRP,
If I'm already using blood and platelets, then the regenerative properties that can just add something like this and possibly get magic within the body. For me, as a practitioner, I'm like, guys, call Mark, reach up, reach out, reach up to Rise Up Medical and just know I'm serious. mean, I'm not, you know, I'm not incentivized to do this for Mark. Like I don't get paid when they sell equipment, but I just, for me, it's a no brainer.
Mark (53:27.057)
Mm-hmm.
Mark (53:39.065)
Yes, that's right.
Mark (53:47.543)
Absolutely. Yes.
Freddie Kimmel (53:52.802)
You know, everybody, here's what I say too. Everybody has those clients in their practice where money's not a problem. Like money from, and I think those are the perfect people to be like, hey, you know, you've been coming in and we're doing shockwave on the shoulder like once a week for the last eight months. Let's, why don't we, why don't we try some exosomes in this? Let's do a little PRP. Let's do a one-off and let's leave you alone for three months and see what happens.
Mark (54:07.589)
Yes.
Mark (54:17.637)
That's exactly, you know, and it's one thing too that I want to press to this one as well because it's the healing journey. A lot of times too, everybody is used to getting like steroid injections in their shoulders and they feel instant relief.
Freddie Kimmel (54:29.005)
Hmm.
Mark (54:29.381)
The thing about exosome or Acellular Stem Cell Journey is that it is not immediate. You know, and I always have to tell people it's like when you break a bone. The doctor can set it, it can take the pain away, and that's kind of the first step of exosome or stem cell therapy is that you get that anti-inflammatory property that kicks in and kind of brings everything back under control.
but your doctor's not telling you that you can out there and start running again. It literally takes six to eight weeks before you kind of feel that optimal healing. And a lot of times too, and I often deal with this with patients where they're like, hey Mark, I was about to call you and tell you that I'm still having issues in my shoulder. And then one morning I woke up and I had zero pain. And it was that they finally hit that 60 to 90 day mark where the body had fully used the resources and completed the healing process. So it's a thing that will give you longevity, but it's also something I want to always
Freddie Kimmel (55:12.234)
Mm-hmm.
Mark (55:19.769)
warn people be patient with because the true mark any regenerative practitioner will tell you is 60 to 90 days. We don't even want to see people come back until a 90-day mark because we want to make sure that they're fully healed to know whether or not there's still additional work to be done. know and in most cases there's not.
Freddie Kimmel (55:37.506)
Yeah, phenomenal, phenomenal information. Mark, yeah. No, no apologies.
Mark (55:40.117)
The last one I want to say on here too, Freddie, I apologize about this, but a lot of people try to spell rise with an S. It's actually rise with a Z. We created that intentionally because the Z was designed to be a platform to demonstrate that we were trying to elevate everybody's healthcare. So it is R-I-Z-E medical. Rise up medical doctor. Yeah. That's correct.
Freddie Kimmel (55:47.319)
Yes.
Freddie Kimmel (55:57.032)
R-I-Z-E-U-P medical.com. I love it. And we'll have all this in the show notes. People will be able to link and click. And anytime you see this on YouTube or social media or Spotify, we'll have a link back to. Do you guys have a social media platform?
Mark (56:11.397)
We do, and it's actually RiseUp Medical, at RiseUp Medical, and it's on Facebook, Instagram, we're on LinkedIn, and we're doing a little bit more on TikTok. I just have to stop long enough in order to literally create these videos. It's all the projects that I'm involved in, they keep trying to tell me, Mark, I gotta get what's in your head out of your head. And I'm like, I just have to sit still long enough in order to put it out there. So I'm the one at fault for that.
Freddie Kimmel (56:30.434)
Yeah.
That is a separate team. That's not you.
Mark (56:38.425)
Yes, it truly is. It truly is. That's why I enjoy the podcast. We get to jump on here and spend quality time with you and reach a large audience. So again, I can't thank you enough,
Freddie Kimmel (56:43.67)
I know.
Freddie Kimmel (56:49.964)
Yeah, you got it, you got it. Be well, thanks for being a guest on the Beautifully Broken Podcast. Big love.
Mark (56:54.779)
Thank you so much.
