GLP-1 Side Effects, Longevity Science, Light as Medicine, and Fasting with Nathalie Niddam
Sep 22, 2025
WELCOME TO EPISODE 259
In this episode of the Beautifully Broken Podcast, Freddie Kimmel is joined once again by Nathalie Niddam—nutritionist, biohacker, and creator of the Longevity and Peptide communities. The two dive into an honest and practical dialogue about what it really means to support the body in today’s world.
Freddie shares updates from his own journey, including building the Biological Blueprint Academy, his personal experience with GLP-2 microdosing, and how technologies like the Avacyn and blood flow restriction training fit into his healing toolbox. Nathalie explains the evolving science around GLP-1 agonists like semaglutide, the recent headlines linking them to vision issues, and why safe dosing and practitioner support are critical.
The conversation also explores:
• Why light is a foundational nutrient as important as food.
• How “stacking” therapies can either synergize or overwhelm the body.
• The importance of journaling and self-tracking when experimenting with peptides.
• The distinction between true foundational practices and enhancement technologies.
• Fasting as both a physiological and spiritual discipline.
This episode blends cutting-edge science, grounded health principles, and lived wisdom—reminding us that while peptides and devices can accelerate progress, they will never replace the basics: movement, environment, light, sleep, and community
Episode Highlights
[00:00] – The risks uncovered: Dramatic drops in glucose and weight, and the rare but serious possibility of optic‑nerve damage with GLP‑1s.
[01:16] – Freddie’s health update and the surprising wellness wins worth celebrating.
[04:47] – Nathalie on environmental overload, “stacking” inputs, and tuning into body signals.
[06:16] – The energetic layers behind biohacking—and what happens when you’re too sensitive.
[10:01] – Building Peptide Parlor, fostering a longevity-minded community, and embracing collaboration.
[11:53] – Supplement overwhelm, industry bias, and the importance of prioritizing body signals over protocol.
[22:08] – Reframing GLP-1 use: sustainable weight loss, psychological shifts, and the pace your body prefers.
[35:49] – Understanding semaglutide, tirzepatide, and red-atrutide—and why more isn’t always better.
[45:10] – Blood flow restriction, Avacyn, vibration, and microcirculation: stacking devices with intention.
[51:29] – Fasting mimetics vs. true fasting: metabolic benefits, risks, and the deeper layers beyond restriction.
[56:01] – Nathalie’s peptide story: CJC/Ipamorelin, mast cells, histamine flares, and learning what not to do.
[01:10:56] – Stem cells, exosomes, Therium testing, and how to track longevity with real biomarkers.
Links & Resources
Nathalie Niddam’s website/membership community:
Upgrade Your Wellness
BEAM Minerals: beamminerals.com/beautifullybroken
Code: BEAUTIFULLYBROKEN
LightPathLED: lightpathled.pxf.io/c/3438432/2059835/25794
Code: beautifullybroken
Silver Biotics Wound Healing Gel: bit.ly/3JnxyDD
30% off with Code: BEAUTIFULLYBROKEN
StemRegen: stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52
code: beautifullybroken
CONNECT WITH FREDDIE
Work with Me: https://www.beautifullybroken.world/biological-blueprint
Website and Store: (http://www.beautifullybroken.world)
Instagram: (https://www.instagram.com/beautifullybroken.world/)
YouTube: (https://www.youtube.com/@freddiekimmel
FULL EPISODE INTERVIEW
EPISODE TRANSCRIPT
Freddie Kimmel (00:01.515)
Ladies and gentlemen, welcome to the show. We have a repeat offender, Natalie Nidham. How you doing?
Nathalie Niddam (00:07.886)
I'm I'm better now that I'm with you. How are you? Thank you.
Freddie Kimmel (00:10.225)
Oh, I'm good. I'm so good. I'm so good. I tell you, I have been the most compliant with the principles that I teach around the ethos of kind of being, not doing, consistency over intensity, not this hypervigilance that I've ever been in my world of wellness. And I feel good. I really do. I feel...
Nathalie Niddam (00:36.664)
Good, good.
Freddie Kimmel (00:39.309)
the least pain I've ever had in my life. Unbelievable bowel movements. I've been sleep, I started to sleep really good. You know, that's always been a struggle for me. Yeah. Joint intended pains, like pretty, pretty nil right now. I've really got things dialed in and I just feel, I feel grateful. I did push myself to the edge last week in just eight months of almost a thousand hours of work creating this, this Academy, biological blueprint. Yeah. Yeah.
Nathalie Niddam (00:48.438)
Mm-hmm.
Nathalie Niddam (00:52.428)
Nice.
Nathalie Niddam (01:04.813)
Congratulations. Yes. Yeah.
Freddie Kimmel (01:08.891)
So I'm having a little, this is like the postpartum week. I launched it on Saturday and I literally feel like, I feel sad. There's a sadness of like, what am I gonna do? I mean, listen, there's plenty of work to do. I know, I know, I know, I know. How are you? Give us an update. It's been over two years since you've been on the podcast.
Nathalie Niddam (01:11.704)
Yeah.
Nathalie Niddam (01:21.774)
Now you're going to execute it. That's what you're going to do.
Nathalie Niddam (01:32.654)
I'm good. Thank you. mean, I'm, you know, still doing the thing. I'm busy. I'm really focused on the podcast. I'm focused on, I have a community, like a membership community that, you know, has kind of, it's a nice size. It's not super big. It's quite intimate, but it is a beautiful mix of very astute consumers and really...
Freddie Kimmel (01:56.41)
Mmm.
Nathalie Niddam (01:58.798)
enlightened kind of like some really nice practitioners who are in there as members as well. So it's this really beautiful kind of coming together of critical minds and there's respect from the practitioners to the consumers and vice versa. It's a, it's a really nice little ecosystem. I'm really grateful to have it. mean, I think I learned as much from them. I know I learned as much from them because I can't have eyes everywhere. Right. Somebody just posted yesterday.
Freddie Kimmel (02:25.573)
Yeah.
Nathalie Niddam (02:28.15)
an article about earwax and how there's some really interesting research coming out about how you can detect certain types of cancer from the metabolites that are released in earwax in the body and the beauty and not just cancer, like all kinds of different metabolic imbalances. And the reason being that the wax
Basically, these are lipid soluble molecules instead of what you get in blood, which are water soluble molecules. So you're getting a different view of what's happening. But who would have thunk that this disgusting sticky gunk in your ears actually is this treasure trove of information. So, and I learned that because somebody in the group said, look at this article I just came across. And I'm like, I didn't see it. So it's just really, it's just really interesting. It's it's a very, I'm very, I feel very lucky.
Freddie Kimmel (02:59.633)
Mm-hmm.
Freddie Kimmel (03:08.997)
Yeah.
Nathalie Niddam (03:21.656)
to get to do what I do.
Freddie Kimmel (03:21.669)
Yeah. Yeah. I mean, that makes, I have no pause around that. You know, the metabolomics, like the metabolomic activity of all cells is anywhere and everywhere. doesn't separate. It doesn't suss itself out. And I'm only going to live in the skin and I'm only going to live in your dental microbiome. No, it's anywhere and everywhere. We really are quantum beings in our expression of vibrancy.
Nathalie Niddam (03:29.911)
I hear it.
Nathalie Niddam (03:39.266)
Yeah. Yeah.
Nathalie Niddam (03:44.847)
Yeah. Yeah. A hundred percent. And you know, the whole quantum field, which is a field that I, I would like to understand more, but I'm at a point where I acknowledge and receive it. feel like it's one of those things I don't need to fully understand to appreciate that there's, there's more to energetically than what we just see.
Freddie Kimmel (04:12.827)
Mmm, yeah.
Nathalie Niddam (04:13.036)
right? Then what we can touch and see, there's this whole other felt and even not felt sphere that affects every piece of our existence.
Freddie Kimmel (04:26.497)
This happens to me about two times a week is that I'll think about a person and I'll think about reaching out and calling them and what I'd like to express. And sometimes I'm just going. so I might have that conversation alone in my head. And oftentimes in that moment, they send me a text. They said, Hey, I'm free right now. like, this is no, you're not. What, do you do? Are you kid? Get out of my head.
Nathalie Niddam (04:42.69)
Yeah. Yeah.
Nathalie Niddam (04:47.714)
Yeah, get out of my head.
Freddie Kimmel (04:50.555)
But it's so it happens so often and it's often mirroring exactly what I was saying in my brain. Like I always I always tell people, you know, when when we're talking about tack or or amp coil or Brown's gas or some of the things you and I love that I'm like, I'm so sensitive. I'm hypersensitized. I can feel my circulation. Like you don't have nerves. And I'm like,
Nathalie Niddam (04:57.452)
Mm-hmm.
Freddie Kimmel (05:13.697)
I can feel the microcirculation on the left side of my body. If I put a coil on the right, I can feel the pulsing inside my, I'm just sensitized to energy. And so I think there's something with that clarity and that attunement and time and stillness and this, you really do come up layers and you're like, life is different when you're this tuned in. It really is different. Yeah.
Nathalie Niddam (05:21.356)
Mm-hmm. Yeah.
Nathalie Niddam (05:40.045)
Yeah. Well, you're very set. You're, would say that you, you, yeah, exactly. Tuned in is the exact, is the exact way to put it. And I think that being tuned in requires stopping. Right. And, and, and I think one of the mistakes we all make, and I'm included,
Freddie Kimmel (05:52.241)
Mm-hmm.
Nathalie Niddam (05:57.719)
is we start stacking stuff. It's like, my God, I only have so many hours in the day. I want to do this. I want to do this. I want to do that. Okay. I'm going to do this while I do that and do this at the same time. And sometimes those stacks are synergistic and they make sense. And sometimes, frankly, we're sending too many different signals at our body at the same time. And who knows what's happening either they're canceling each other out. If we're lucky, they're amplifying, but if we're not lucky,
Freddie Kimmel (06:09.445)
Mm-hmm.
Nathalie Niddam (06:21.626)
It could even be just too much information. don't want too many instructions, right? It's like, imagine you've got this worker right there and it's ready to do that. Worker's ready to do what you want it to do. And then you start sending it seven different information, like seven different instructions simultaneously.
Freddie Kimmel (06:39.791)
Yeah. Yeah. I often say it's like, because people ask, they're like, well, can I do, can I do PEMF and a frequency device and hydrogen gas and red light? I'm like, well, it's, they're all, it's information. It's an information packet. And so is a peptide is an information packet to the body. And if I sat you down and said, Hey, we're going to learn a new language today, but I want to work on Italian, Greece and French at the same time. What would your, how would your consciousness take then that information?
Nathalie Niddam (06:55.202)
you
Nathalie Niddam (07:03.18)
Yeah.
Freddie Kimmel (07:08.625)
It wouldn't. You would learn nothing. So again, what do you want? How do you feel? And what's your experience? If you stack two or three things and you always feel incredible, I'm like run with it. But if you're not getting, if you're not making progress, and I think this is the thing where, this is the thing where I'll go back to a journal. Can you journal every day and tell me how your state, your cognition, how your heart feels? Is that moving forward or are you treadmilling?
Nathalie Niddam (07:21.39)
Yeah.
Nathalie Niddam (07:33.655)
Okay.
Freddie Kimmel (07:38.673)
Because you sound like you're on a treadmill. It sounds a little manic when you're trying to put things together. What would stillness feel like and what are you afraid to look at or feel or listen to in the stillness?
Nathalie Niddam (07:38.85)
Mm-hmm.
Nathalie Niddam (07:42.658)
Thank you.
Nathalie Niddam (07:48.537)
Yeah, no, that's, that's beautiful. And that's, it's important. And I don't want to say that I'm knocking stacks at all, because if you happen to use methylene blue and your red and near infrared light at the same time, we know that they work together. So I think that part of it is being intentional and just not trying to slam it all in at this, because you're trying to make use of this 20 minute window that you happen to have. And you can, right? So methylene blue plus red near infrared light.
Freddie Kimmel (08:07.089)
Yeah.
Freddie Kimmel (08:14.35)
Yeah.
Nathalie Niddam (08:17.866)
Amazing. Drink some hydrogen water. Fabulous. be, but you know, do you need to have the katsu bands on at that moment? Maybe. I mean, there could be some benefit, right? But, but just slow down and, and do go through that process of intentionally saying, okay, why am I doing what I'm doing when I'm doing at the same time?
Freddie Kimmel (08:22.289)
Mm-hmm.
Freddie Kimmel (08:29.521)
Sure. Yep.
Freddie Kimmel (08:34.971)
Yeah.
Freddie Kimmel (08:42.969)
Yeah. Yeah. Have some rationale or understanding or have a concept and then prove it out for yourself. Prove it out for yourself. Give it 90 days. Can you go back and can you give us the, what's the name of your community?
Nathalie Niddam (08:48.728)
Yeah.
Nathalie Niddam (08:55.626)
it's called, it's longevity. It's the longevity community. It's, for P if people want to look, people want to check it out. It's all on my website, natnidam.com. actually have two membership communities. One of them, one of them, I started as a refuge for the Facebook community. So the Facebook community, which is, I don't know, I think I'm barely in there anymore. I think it's 35,000 people, but we got, we ran a foul of meta.
Freddie Kimmel (09:22.35)
Mm-hmm.
Nathalie Niddam (09:24.916)
a couple of, a few months ago where they virtually shut it down. They, you know, it got very ugly. and the problem with Facebook is you have to, you know, once you land in their crosshairs, you have to mask your language. You're not allowed to talk about certain things and they can shut you down from one minute to the next. So what I did is under the umbrella of my bigger membership community, where I do
the weekly office hours, I have guests from podcasts come in and do live Q and A's. we, you know, we have this very robust community. I created another one called the peptide parlor, which is it's five bucks a month. So it's really enough just to cover, cause I have to pay people to moderate it. You know, like there's something people don't realize there's expenses involved in this stuff.
Freddie Kimmel (10:00.635)
Mm-hmm.
Mm.
Freddie Kimmel (10:11.699)
well what about your time? That's free.
Nathalie Niddam (10:14.23)
And then there's that. So I'm in there like once. So I'm, I've committed to being there once a month and I've got another moderator who's incredibly knowledgeable. Frankly, I think she knows more than I do. She's in there more also once a month. And, and we do, and what we've done is we've created a safe container for them where they can have the discussions they want to have without worrying about coding any number of terms, which frankly, that bar moves from one day to the next. we have peptide parlor, which is.
Freddie Kimmel (10:23.643)
Yeah.
Mm-hmm.
Nathalie Niddam (10:41.474)
this little $5 a month community. And then there's the longevity community, which is, a little more of an investment, but it's much more robust. Sometimes I get to, I can negotiate like really great deals for them on certain products and testing, stuff like that. it's all natniddam.com. It's all on my website.
Freddie Kimmel (10:48.817)
Hmm.
Freddie Kimmel (10:58.873)
I love it. I love it. I love it. So yeah, you've done such a great job at cultivating good community and you're such a trusted source. again, you're in it. You you're in the trenches. So you understand, I think better than anybody, a theme that's been coming up for me a lot with interviews and again, trying to how do you create material that's educational, but we remove this bias. And it's so
Nathalie Niddam (11:00.578)
Thank you.
Freddie Kimmel (11:25.649)
I see it all the time. I don't think our world of whole, whole ism, holistic health is any better than the pharmaceutical industry in it's the dark side of incentive. Like I, I will be the first to admit, like there is a re I recommend light path LED. I know Scott, he's a family friend. I've known him for 20 years. I trust him implicitly. Is he, is it the absolute best red light panel on the market?
Probably not. However, do you know what I mean? There I'm like, well he gives
Nathalie Niddam (11:58.915)
Well, is there, is there an absolute best? There are many good panels. are some, some sketchy players, so we need to be mindful of those, but there are many good panels, right? Just as there are many, like there's many different supplements or whatever the case may be. I think what people look to us for is our integrity. Do we, do we believe in, do we trust the people that we
Freddie Kimmel (12:02.257)
That's right.
Freddie Kimmel (12:08.923)
Yeah.
Yeah.
Freddie Kimmel (12:16.443)
That's right.
Freddie Kimmel (12:20.667)
Yeah.
Nathalie Niddam (12:26.006)
represent, whether we interview them on our podcast or we promote their products. And the other thing that I think is very important for people to know is we represent, we promote, we talk about, we educate. It doesn't mean that everybody needs to buy everything. And that is difficult, right? Like at the end of the day, and I'm sure this is what your academy is about, is creating the discernment, creating the
starting to create the understanding of what do I need now? Does this speak to me right now? Like, I mean, this, you know, this, what was it that I I did a podcast on a supplement not too long ago and people started messaging me going, my God, like there's so many things, like, what do I choose? And I'm like, well, you sit with your practitioner. You understand where is your health today? What are your goals? What are you trying to solve? What are you trying to optimize? And now we look at this
beautiful buffet of options and we start to select what are the things that are going to get us to where we need to go. And it could be that there's too many things to do all at once. That's okay, because maybe what we'll do is we'll pick a collection now and in three months we're going to cycle off of them and move something else in because again, the body needs different things at different times and that's, that's all right. So, you know, and it's like what you're, mean, I have a light path LED upstairs. I love that thing.
Freddie Kimmel (13:52.473)
Mm-hmm, yeah.
Nathalie Niddam (13:52.557)
Right. It's, it's a beautiful piece of equipment. I use it every single night. Right. It's, my nightlight in my bathroom. I use it every night and on my desk, I have a different panel because this one, when, you know, it has a setting that I'm not using right now, but the setting I'm using right now is called fireplace. And so what it does is it allows, it basically offsets the blue light, the artificial blue light coming off my computer.
Freddie Kimmel (14:01.179)
Yeah.
Freddie Kimmel (14:19.279)
Mmm. Yeah.
Nathalie Niddam (14:21.282)
Which is, it's not, I mean, I'm not super close to it. It's not intended to be particularly therapeutic, but it is intended to offset that blue light. It's made a big difference to my energy, but it also has a setting that allows my body to make its own vitamin D, which I will use for five minutes a day. And that to me is really fascinating because I don't know if you've seen that, but I've seen that there are people who can supplement vitamin D till the cows come home and their body just can't use it. Their levels never seem to move.
Freddie Kimmel (14:26.566)
Yes.
Freddie Kimmel (14:35.441)
Mm.
Nathalie Niddam (14:51.234)
And they use a light like this, the body's own system all of a sudden kicks in. They make their own vitamin D and things start to move.
Freddie Kimmel (14:59.993)
Yeah. Yeah, it's really interesting again, putting this together. everything is medicine, right? Light is medicine. So having that conversation with, you know, I want to understand if I'm, and I've been really diligent for over a year of when I wake up, I take an outdoor shower. If it's in winter, I take it, I'm in Texas, right? So I'm up. I can do that. But I'm on the ground. I'm grounded.
Nathalie Niddam (15:08.619)
I'm sorry.
Nathalie Niddam (15:19.106)
Yeah, you can do that.
Freddie Kimmel (15:26.777)
I'm getting 10 to 15 minutes of light. take a long ass shower outside. Then maybe there's like a morning puppy walk or morning puppy pee. And I'm diligent to get in that level. And then I'm also aware that if I go through this last eight months, predominantly working inside for eight to 10 hours every single day, I'm not outside enough to make my adequate levels. So then I have to change my supplementation. I correlate that with my labs.
Nathalie Niddam (15:27.075)
Mm-hmm.
Nathalie Niddam (15:45.922)
Yeah.
Freddie Kimmel (15:53.87)
and I'm making a plan that works for me so I have enough light. Because I can't skip that. mean, listen, you can. I can do anything I want. There will be repercussions to my long-term health. Consequences which I'm like, if you're leaving light on the table, whoa, baby, we got, it doesn't matter what you're eating, carnivore or vegan. You need light in your life. It's a big one because what's food broken down to? Light, the light energy.
Nathalie Niddam (15:57.517)
Yeah.
Nathalie Niddam (16:03.15)
There'll be consequences. Yeah.
Nathalie Niddam (16:17.644)
Yeah. Well, and you know, you know, there was a study and I've lost track of it now. I'll have to find it one of these days, but there was a study done that had two groups of people eating the exact same food. One was indoors under artificial light and the other one was eating outside. And the effect of that food on their metabolism was completely shifted when they ate in natural light away from the artificial blue light. And so if that's not enough to
to show, tell us that light is a food to our body and it's a fuel to ourselves. And it affects the way that we interact with other inputs in our system. And I don't know what is right. So that now, so, you know, I don't live in a climate where I can be outside all the time when, when it's summer and spring and early fall, and anytime I can be outside, I will, but you know, I'm then in a world where I need to, how can I mitigate?
Freddie Kimmel (16:58.275)
Mm-hmm. Yeah.
Nathalie Niddam (17:16.29)
the impact of too much indoor time, just as you did.
Freddie Kimmel (17:19.247)
Yeah. Yeah, environmental force supplementation. And I have this great slide of a fish, of a two fish bowls. One's really beautiful and sparkling and one's just full of mold and fungus on the glass and the fish. You know, what is that? Does that fish need methylene blue? No, we got to drain the tank. We got to clean that water.
We got to clean that water. So order of operations, think, is just, it's common sense, but we lose that discernment sometimes when we go down these rabbit holes of like you're saying, what do need to buy? What's the supplement? What's the next thing I need to get into my stack? It might just be adjusting that environment, which I always, you know, that's the first thing people are like, do I need this device? I'm like, I don't know. I have 20 questions for you before we even go.
Nathalie Niddam (18:06.828)
Yeah. And, and, that's a great place to start, right? Let's start with 20 questions. And I mean, there's, you know, there will, there will always be devices that, and I think a lot of the devices that we've talked about, like the Brown's gas machine, the, have the Nano V downstairs. You have a Nano V in your lab as well. these are, these are devices.
Freddie Kimmel (18:10.064)
Yeah.
Freddie Kimmel (18:21.425)
Mm-hmm.
Nathalie Niddam (18:31.726)
for people who can get access to them, and we can't always, but if you can get access to these, whether it's in a clinic or you are fortunate enough to be able to make that investment for yourself, these are foundational practices, right? And to some degree PMF is the same. It's foundational. It's because it's bringing energy. it's bringing, it's bringing something to the cell that allows your body to do what it does naturally.
So it gets so far upstream that it can help to solve puzzles, if you will, in the body that because, I get this angry comment on Instagram all the time, stop telling people, that people will say to me, stop telling people to buy things, just get outside, eat real food and move your body. And I could not agree with you more, except for one little point. If you're living in a major city right now,
Freddie Kimmel (19:00.806)
Mm-hmm.
Freddie Kimmel (19:08.251)
Mm-hmm.
Nathalie Niddam (19:29.804)
Your body is being assaulted by so many things, whether it's non-native EMFs, pollution in the air, pollution in the water, all the things that our bodies can, maybe they'll adapt to them one day. I don't know. you know, we're, human evolution is a powerful thing, but it ain't going to happen today. So we do unfortunately have an, in order for us to feel and function our best.
We have to figure out ways to mitigate some of these overloads that we're being faced with right now, even chronic stress, frankly. I I don't think there's a group of people on the planet right now that's not experiencing some kind of stress.
Freddie Kimmel (20:05.933)
Mm-hmm. Yeah.
Freddie Kimmel (20:16.505)
Yeah, yeah, it's profound. where we're at. Again, it's that I want to meet you where you're at, which we would discover. Would we be able to sit down for 25 minutes? And I think that's where I didn't, you know, there's so many beautifully brilliant people in this space. was like, I don't need people, don't need my opinion. They don't need my course. And I was like, well, actually,
there's some good foundational principles that I guide by that I do think are valuable and have really worked well. And it's like, can't, I don't have two hours to give everybody, you know, a lifestyle intake and a quality of life and a sleep biome questionnaire. And, you know, I, I have 10 questions about your poops, you know, all the things, but I can, but I can create, I can create a outline for you and I can teach you how to do it for yourself. 100%.
Nathalie Niddam (20:48.962)
Yeah.
Nathalie Niddam (21:06.561)
Yes.
Freddie Kimmel (21:15.841)
And you know, that was the, I really tried to stick to is to have no tech involved in the course.
Nathalie Niddam (21:22.286)
Yeah, as a starting point, there should be no tech. There should be no tech, not until you've really kind of gotten a sense, because maybe that'll guide you to which tech, right? And so, yeah. What's first?
Freddie Kimmel (21:25.434)
None.
Freddie Kimmel (21:32.282)
Yeah. Yeah. Yeah. You know, it's, yeah, it's first, it's environment first. It's movement is life. Motus was, you know, we can't undo. I see this all the time. My nervous system at the end of the day, if I do sit at the desk, I can't undo it, you know, through tech. I have to walk 10,000 steps. I have to get enough movement or I can feel, I can feel a tension index that starts to build in my tissue.
Nathalie Niddam (21:55.182)
Okay.
Nathalie Niddam (22:01.187)
Yeah.
Freddie Kimmel (22:01.329)
And you know, I may be able to mitigate that with six grams of glycine and dark tart cherry and hopefully get a good night's sleep, but it's a different story. If I wake up, do some breath work, go for my morning walk with a weighted vest and just get that chi moving. And there's a natural exhaustion that happens as a result of living by these principles. It really helps. I want to...
Nathalie Niddam (22:23.886)
Thank you.
Freddie Kimmel (22:29.935)
I want to talk a little bit about peptides because do you have a, do people give you a title for your peptidism? Are you, you know, there's like the lymph, there's like the lymph queen or the lymph king or the lymph guru. there, are you the peptide queen?
Nathalie Niddam (22:32.92)
Mm-hmm.
Nathalie Niddam (22:39.426)
People, there's all kinds of titles, but yeah.
Nathalie Niddam (22:47.406)
People call me that. I don't love titles on this stuff. think that, I think that peptides are, I mean, I've been studying and talking about and supporting people with peptides for a very, quite a long time. mean, not that long really, if you think about it in the grand scheme of the world, but let's say six or seven years. and, and I, I just think it's such an evolving, it's such a fast evolving field and I'm not.
Freddie Kimmel (22:50.722)
I- Sure.
Nathalie Niddam (23:16.558)
I just, like at best maybe peptide educator, know, like, or peptide guide. and I cringe when people call me a peptide expert, just because I think expertise is, it's a different, it's a different sphere. But I mean, maybe that's just me, you know, but anyway, I'm, I'm, I'm happy to be a peptide guide for people.
Freddie Kimmel (23:42.106)
A peptide guide. Well, I love that. And I consider you a peptide queen. You're my... Because I know how you operate and I know your integrity. Often, you're my go-to for questions. I would love to start with, if you're open to talking about it, you know, we just had this big new story in the last two weeks about a massive lawsuit against some of these GLP-1 agonists in the space and blindness.
Nathalie Niddam (24:04.907)
Mm-hmm.
Nathalie Niddam (24:11.394)
Mm-hmm.
Freddie Kimmel (24:11.663)
What? What's happening there?
Nathalie Niddam (24:14.198)
So it's really interesting. It's, I think there were out of, so it's, it's so odd that we're talking about this now, cause last night I was, had a conversation with a medical doctor about this very thing for, for a peptide summit that I'm co-hosting in October or November, maybe anyway, whatever upcoming. and, and I'm like, we need to talk about this, right? Because this is, this sounds scary.
this, when I read the article, the article in the paper or the media, it was like people waking up in the morning, fully completely blind overnight and it's irreversible. So the way the story goes, and she had done a deep, deep dive into the paper. Number one, this came out of an eye clinic, a, it was this, this clinic was a special specialized in eye.
problems and I can't remember the exact term for it. So they are more likely to be seeing people with vision problems. But when it comes to the, to the role the GLP one is playing in this, in this issue. So number one, think number two, sorry, I already used up my number one, number two, only two people actually went totally and completely blind, but regardless, if you lose any vision, that is a horrible, terrible problem.
It was 37 people out of 16,000. This particular condition where the optic nerve gets loses its blood supply happens on a regular basis in two in 100,000 people in regular population. So clearly there's a problem here. 37 out of 16,000 versus two out of a hundred thousand. have an exponentially higher risk. But what she was telling me yesterday is that.
The people who developed this condition, I believe it was every one of them had seen very fast and dramatic drops in blood glucose and in weight. And the problem is that nobody can figure out what is the mechanism of action that could cause, the complete constellation of what we know that GLP-1s do, how they affect the body.
Nathalie Niddam (26:35.32)
There's no mechanism of action that explains this. But when, when people lose a ton of weight and their blood sugar drops very fast, there are, this can happen. There's some, somehow this can be a consequence. So what she said, and what I really agree with is in all the cases, these people had experienced a dramatic and fast.
shift in their bodies. The body doesn't adapt very well to very fast, dramatic shifts. So is it possible that these people were on very aggressive doses that very early out of the gate and that caused them to drop so much weight that created such a crazy shift in the body that somehow this resulted in a loss of blood flow to the optic nerve. The other, I'm trying to remember
The other thing that she said is that virtually every one of these people had major metabolic imbalances to begin with. So we're dealing with a population of obese people that are metabolically imbalanced whose bodies are already struggling. And is it possible that they were put on such a high dose so fast? So maybe they weren't titrate. And there's not a lot of information about that in the actual paper. the nut net of it is that
They're still, I hope I didn't put my foot in it. I'm going to have to check this, Freddie. You may have to edit this part out because I'm not sure if they were all obese or if they all had an eye condition. So I'm going to have to go back and look that up. But what we know is that the chances of this happening are still very small.
Freddie Kimmel (28:19.941)
Okay.
Nathalie Niddam (28:30.702)
Even though 37 out of 16,000 of this population was debt is a big number, you know, you're still rolling the dice. Right. So, so I think that we still, there's still a lot more information that needs to be gathered to understand exactly what is happening and what might be driving it. Um, it is also without a doubt that the GLP ones are still helping so many more people.
than are having issues, but that does not mean that we close our eyes to people who are developing pancreatitis or people who are developing gastritis or people who have intestinal blockages. These are all things that can happen from GLP-1 use. So what it does is it underlines and highlights and double-bolds the statement that if you're going to be using one of these compounds,
Be working with someone who can help to guide you and don't be in a flippin rush. Like you didn't get to where you are today in three weeks. Give your body the time and the grace and the support to gradually release and to detoxify as you're going. Because the other thing that she mentioned, which is very true, and you know this as well as I do, where does the body sequester toxins? In the fat.
Freddie Kimmel (29:38.321)
Hmm.
Freddie Kimmel (29:54.34)
in the fat.
Nathalie Niddam (29:56.375)
You start dumping, you start melting fat overnight and you start dumping all these toxins in the body and you compound that with constipation, which is a very real side effect of the medication they were talking about in particular, which is semiglutide, which is Ozempic. So now you've got a backup in the bowel that, that major exit for toxins is blocked. You're melting fat. So toxins are flowing through the body. They're looking for a place to hang out.
You now have a perfect storm, right? The first thing I learned when I was in school to study nutrition was before you start any detoxification program, make sure that the doors of exit are open. That's the liver. That's the lungs. That's the sweat glands. That's the colon. And that's the kidneys for urine. These are the ways that your body has to expel toxins. So unfortunately you've got a lot of people who are
really motivated to move the needle here, they're not getting great guidance or they're not looking for good. They're probably not just not getting great guidance or they're taking matters into their own hands and they're just going out. Sometimes a lot of these telehealth providers, you've got a 20 minute phone call. Great. Write your prescription off you go. There's no support. And now all of a sudden you've got people using things.
possibly before they're ready or not supporting their bodies while they're using them. So, you know, to go back to that one K that one study, is there a problem? Yes. Is it widespread? No. Does anybody want to take the chance that they're going to wake up blind one morning? Cause they tried to drop 10 pounds. Heck no. Right. So we need more information. need more context in that situation. And.
We also need to be really, really respectful of both the body and of what these very powerful and useful drugs can do for people.
Freddie Kimmel (31:57.936)
Yeah. Yeah, it's very much follows the guiding principles of nature. Like when we step outside of those guiding principles, there really are not shortcuts. Like there is a system of checks and balances within the body that we often find will swing back around at some other time in life. And I've always thought of it like, you know, here we are in a society where, you know,
Nathalie Niddam (32:16.365)
Yeah.
Freddie Kimmel (32:27.203)
I always look to the neurological conditions of Parkinson's and Alzheimer's and our risk, you we're doubling. We're doubling our numbers since the nineties. And, you know, whether you want to call that metabolic dysfunction, but that's a piece of it. That's a piece of it too. Just because we see like a label of neurological degeneration in a portion of the population, it doesn't mean that others are not experiencing some level of this, but they have not been labeled.
So there's this piece that goes into it where, again, you're mentioning on a 20-minute call, can I get the drug to treat the thing? We're not observing the other mechanisms of action in the body. Again, because we're trying to spot treat the weight and not understanding it's a bigger picture, and that's just not the way our system is built, it makes sense that we have these people that are experiencing, unfortunately, that people are experiencing these.
Nathalie Niddam (32:57.365)
Mm-hmm.
Freddie Kimmel (33:26.895)
really negative side effects associated with eyesight. Can I ask?
Nathalie Niddam (33:30.13)
And there's significant, mean, I just think we need more information. And I also think that if you think you're just going to use a GLP one and not change anything else in your world, you're heading for trouble, right? You're, just heading for trouble. So, you know, and I, should we call it a perfect world or should we call it a world where we step up and take ownership and say, you know what?
Freddie Kimmel (33:44.241)
Yeah.
Nathalie Niddam (33:55.925)
And, and, and frankly, sometimes people they're not eating as they're not eating enough. They're not moving enough. They're not sleeping. Their hormones are out of whack. Their eating habits are horrible. Right. They've, eat the wrong foods. So all of those pieces need to be addressed and I'm not saying they need to be at, and they're not pooping. They're not sweating. They're not doing all the things. So all of these pieces need to be addressed and I'm not going to hold out the carrot and say, you don't get to have this.
until you've done that. Because for many people, they can't get out of their chair because they're in so much pain. They're so overweight. Their bodies are so stuck. Their metabolism is so out of whack from years of yo-yo dieting or whatever, whatever it is that got them to this state. If we can offer them something like a GLP-1 at a lower dose and gradually work them up to a place where they start to experience a shift and stop them there.
Don't keep going, just stop at that minimum effective dose and provide this person with enough relief that now all of a sudden they start to sleep better. They're a little bit lighter on their feet. Their inflammation is down. They don't have as much pain. They want to go for a walk. They want to go outside. They're motivated to eat better food. We've now assisted people in making the shift as opposed to having this kind of hard ass, eat less, move more, and then we'll talk.
Freddie Kimmel (35:23.313)
Yeah. Is there... Now you said, you say the word, I'm not a peptide educator, or, you know, it's very, I understand some concepts. You said GLP-1. Now there's GLP-2s and there's GLP-3. There's triple agonists and double agonists. Are there any, is there any nuance within that study? Is it people just doing semi...
Nathalie Niddam (35:24.674)
That's not also not fair.
Nathalie Niddam (35:48.972)
They only studied semaglutide.
Freddie Kimmel (35:50.629)
They studied stemaglutide. how is stemaglutide? GLP-1.
Nathalie Niddam (35:52.579)
But which is a GLP-1. So GLP-1 is the molecule. We make GLP-1 in our gut. This is part of the reason why, you know, it's kind of a little bit hard to understand what the heck is going on here. And it might not be the molecule that's doing it, but it might be the effect of the molecule. And that's where her point of people dropping blood sugar too fast or dropping weight too fast is causing a shock to the system and is somehow
Freddie Kimmel (35:58.929)
That's right.
Nathalie Niddam (36:19.338)
expressing itself in this population in their eyes. Like we know the diabetic people are susceptible to vision issues.
Freddie Kimmel (36:29.509)
Yes, that's right. Diabetes is associated with blindness.
Nathalie Niddam (36:33.646)
Correct. So is it about the mechanism and how things are happening more than just that one thing? Now the question you asked, GLP-1, GLP-2, GLP-3, semaglutide is, we call it a GLP-1 because the only active compound in there is the GLP-1, which is an analog of the GLP-1 we produce in our gut. It's been modified, right? Because they discovered in Gila monsters that they...
They produce a peptide very basically that's a GLP-1, but that had a much longer half-life. So they went back to the lab and reverse engineered it and created this GLP-1 molecule that acts on the GLP-1 receptors that has a really long half-life, which is why people are able to use it once a week. Now the next generation, which is Mungero slash Tersepidide is a GLP-1 and GIP. So now you have two different mechanisms of action.
So you're still going to have the GLP-1 in there. And it's possible that this blindness issue might pop up down the road with terzepatide as well. But is it possible that with the GLP-1 and the GIP, there's some other interaction that is, nobody knows, right? And then the next iteration, which isn't even actually officially out to market yet because it hasn't been approved. And so the hope is that it will be approved in 2026 or early 2026 is red atruteide. And now what we've done is we've added glucagon.
Freddie Kimmel (37:44.795)
We don't know.
Nathalie Niddam (37:59.927)
And so glucagon in, in a lot of the, in with the other two can really tank. And what we're doing is we're adding glucagon to stabilize. And by all accounts so far that we've seen is that it is, you know, tersepid is more, can be better. And it's not always better, but it can be better than semiglutide because it has fewer side effects. It doesn't have the gastric side effects necessarily that semiglutide does.
And now Reddit True Tide has even fewer side effects. It is less, it has fewer effects on appetite suppression, but don't forget that the GLP-1 is still there. You still have GLP-1, you've just added to it. So they're all GLP-1s. They're just, they're just, they're enhanced, right? We've added another piece of the puzzle. And part of it is scientists sitting there going, okay, so what's really happening? shit, glugagons, yeah. Okay. Well, what if we added that back?
could that help to stabilize the system so that people don't go through the same side effects? So it seems that red atrutide when it comes to market, and I know there's lots of people out there already using it because they're getting their hands on it, but red atrutide, it seems that it is the most effective. It is the most efficient at muscle sparing and it has the fewest side effects. Tersepidide has fewer side effects for many people than semicleutide. Now in terms of certain other side effects like
extreme fatigue. That is something that certain people experience and nobody really knows why. It could be an autoimmune issue. Even the pancreas, the pancreatitis could be driven by autoimmune, which is counterintuitive because you've got a lot of people in the autoimmune community that use these, these medications because it calms their inflammation and it, and it actually balances their immune system. But paradoxically in some people it goes the other way.
And so for some people, they, can't tolerate them. They can't tolerate any of them. It's not a lot of people, but it's some people. So here you see it, right? Some people go blind. Some people get extreme tiredness. Some people get pancreatitis. Some people, mean, the intestinal blockage thing that typically it's, that's not inevitable. That's someone who wasn't supported properly and didn't have their eye on the ball. And maybe they were constipated their whole lives, which we both know.
Nathalie Niddam (40:26.39)
A lot of people are constipated their whole lives. Now all of a sudden you slow gastric emptying, you slow the motility of the gut even more. And now you've got someone who's lucky if they go to the bathroom once a week. And now we have a problem. Right? And nobody's talking to them about that until they're, end up in the hospital with an impaction or whatever it is.
Freddie Kimmel (40:39.161)
Huge problem. Yeah, that.
Freddie Kimmel (40:45.903)
That's right. Well, as someone who's witnessed me having a partial small bowel obstruction, that was not your fault. That was not your fault. Now I will tell the audience that tip, know, they know, everybody talked about Freddy's health stuff all the time, but I've all these small bowel obstructions or partial obstruction as a result of scar tissue, something like a GLP-1, the semaglutide, like I wouldn't touch with a 10-foot pole because any
Nathalie Niddam (40:50.28)
yeah, because of my cooking.
Nathalie Niddam (40:59.361)
You
Nathalie Niddam (41:14.271)
idea.
Freddie Kimmel (41:15.001)
Anytime I know that, for me, it's like bad. I already have to do all these things, including castor oil packs and scar tissue therapy and, and PEMF, which has been incredibly helpful for my motility. that's a, that's something I manage like a brush my teeth. It's just part of my, it's part of my radical ownership of my health paradigm that I incorporate. Now, yeah, I will tell you, I am on a micro dose of a GLP two and it has been phenomenal.
Nathalie Niddam (41:25.548)
Mm-hmm. Mm-hmm.
Nathalie Niddam (41:34.156)
Yeah. Yeah. Yeah.
Freddie Kimmel (41:43.825)
at turning down.
Nathalie Niddam (41:44.723)
What's a microdose? me.
Freddie Kimmel (41:47.218)
Oh, goodness. I'm so bad at this. it is, if I'm getting a vial and I'm reconstituting with a full CC, it is like seven ticks on the insulin syringe.
Nathalie Niddam (42:02.702)
And how much is in the vial?
Freddie Kimmel (42:05.465)
It's a 5 or a 10. I don't know. I know. Isn't this so bad?
Nathalie Niddam (42:07.406)
I love people in peptide math. They get so baffled. Anyway, but yeah, so you're using a very low dose and what's it doing for you? Because you're not using it for weight loss. You don't need to lose weight.
Freddie Kimmel (42:12.561)
Bye now.
Freddie Kimmel (42:18.563)
No, I don't need to lose weight. using it for like, again, I would say like it would be the remnants of having Lyme or mold toxicity. that, yeah, and it's, you know, I look at my labs, there's nothing, there's no C-reactive protein, there's no more anti-nuclear antibodies. I run my labs, I don't have active Lyme. However, there is like this synovial fluid piece that just it gets a little inflamed and that's...
Nathalie Niddam (42:31.074)
So inflammation, immune dysregulation.
Freddie Kimmel (42:47.949)
It's really helped. I'm going to say it's like 70 % better when I'm on that microdose on a Monday and a Thursday. Yeah.
Nathalie Niddam (42:53.474)
Mm-hmm. Amazing. Yeah. And that's the thing, right? So a tiny, now these are the challenges, these are off-label uses of the LP ones and the companies that make them are very unhappy about people using them that way, which is unfortunate. I hope that over time they will, you know, we will get to a place where there's enough research and published.
Freddie Kimmel (43:03.046)
That's right.
Nathalie Niddam (43:19.958)
published research that says, here are other applications at different dosages for different reasons. And I think part of it has to do probably with the regulatory landscape where when you release a drug, it has to be for this purpose. We know it does this. We know how it does that. we know, we know, know, we know, we know. But even you look at the GLP-1s being studied, and I think it's semaglutite in particular, is being studied for helping people with Alzheimer's. Because why?
because it helps to restore insulin sensitivity throughout the whole system. And we know that part of the issue with Alzheimer's, not the whole issue, as you said earlier, part of the issue with Alzheimer's and different types of dementia is an inability for the brain cells to get access to energy when they need it. And if we can restore insulin sensitivity, then maybe that is going to be beneficial. It sounds like the trial is going pretty well. So it may become a part of that puzzle, but in your case where you're experiencing
this alleviation of maybe immune, some kind of immune dysregulation or inflammation. Once, hopefully once they've quantified some of these things and how they're happening, now we can start to see these products being basically accepted, not even accepted. They're, they're now prescribed available to be used for those purposes. But it right now we're seeing these companies are very protective of their IP, which I get. mean, look, they've
Freddie Kimmel (44:41.424)
Mm-hmm.
Nathalie Niddam (44:48.248)
They've invested bajillions of dollars into this. So I do kind of get it.
Freddie Kimmel (44:53.189)
Yeah, now that's not the only thing, right? I have a little bit of a stack here that I am doing. I also did lots of chemotherapy. I did as much cisplatin and entoposide as a body could take. They wanted to give me another run. They're like, you know, my veins were burning. I have some wild pictures of myself. I look like not a human. And so that's something where there are very real...
Nathalie Niddam (44:58.284)
Mm-hmm.
Nathalie Niddam (45:06.978)
Mm-hmm.
Nathalie Niddam (45:11.597)
Yeah.
Freddie Kimmel (45:19.761)
I'm gonna have workable things I'll work with for the rest of my life. You I some horrible neuropathy, which again, I have completely reversed through pulse electromagnetic field and frequency through the amp coil completely. I would slap the side of my thighs and I could feel, all I could feel was the vibration. There was no pain. Like all those, you know, you cut some nerves. That's right. And you also cut through
Nathalie Niddam (45:38.858)
Mmm. Hmm. Nervendigs are fried. Yeah.
Freddie Kimmel (45:46.322)
You you cut through a lot of nerve endings when you go into the peritoneum and that retro peritoneal lymph node dissection. Many men never have an erection again. That's I signed a paper and said, hey, just so you know, you might wake up and young guy, 26, this may never work, didn't have a choice. I was like, okay. Luckily,
Nathalie Niddam (45:59.727)
Young guy. Yeah.
Freddie Kimmel (46:12.485)
You know, I was not willing to accept that and I wanted to think a little bit outside of the box. Other things that I've stacked with that GLP-2, which have made a huge difference in inflammation, is this device called the Avacyn that I've been using. Avacyn's a device, and I haven't really talked about it on the podcast. We'll see when this one comes out. I did a little solo episode I mentioned. It looks like a robot mitten and you put your hand in this machine and it creates a vacuum around the wrist, seals your pressure.
Nathalie Niddam (46:27.267)
time.
Freddie Kimmel (46:42.125)
starts to heat the hand and the body thinks that you're overheating. So as it starts to open these micro capillaries everywhere and you just get all the benefits of microcirculation, you start to rebuild capillaries that have been damaged. This has only been about two months, but noticeable difference in pain and
Nathalie Niddam (46:48.715)
interesting. And so it releases all.
Nathalie Niddam (46:57.23)
Mm-hmm.
Nathalie Niddam (47:05.57)
That's amazing.
Freddie Kimmel (47:06.531)
Yeah, it's really great. It's a medical device. I believe they're a Class II medical device. It's an old technology, 30, 40 years old, that's just sort of fallen by the wayside. Sometimes if it's not brand new and groundbreaking, people are like, I don't...
Nathalie Niddam (47:23.948)
It doesn't get the attention. You know, what else does that is your BFR. Like I have the Katsu, have the, yours are, you have the Suji or Saga.
Freddie Kimmel (47:28.529)
That's right.
Freddie Kimmel (47:31.985)
I have a Saga band. have a true analog system where it's just the band without any pressure. I zip it tight. But cognitive boost in the morning, if I put on those arm cuffs, even while I'm typing, I was like, what a great buzz.
Nathalie Niddam (47:47.255)
Yeah, yeah, the katsu is the same. It's the microcircuit, but because it's, you know, what's fascinating about these technologies, and a lot of the research was done on the katsu, is the pulsing of it. But ultimately, when the blood flow is impede, and it's the venous return that's blocked, right? So you get an engorgement of the muscle with blood, you're not able to clear lactic acid.
Freddie Kimmel (48:09.553)
That's right.
Nathalie Niddam (48:15.842)
When you get the buildup of these compounds, the brain, just like with your thing reads, holy crap, we have a problem. And the brain starts to release growth factors. It releases nitric oxide. It releases, growth hormone, like it releases all of these different compounds for repair. And it starts to push and promote the building of new little tiny micro capillaries to get better blood flow. So.
all of these modalities. It's so fascinating, right? Like that, and there's many different ways to skin a cat. We are in this case, contrary to the beginning of our discussion today, kind of tricking the body. We're leveraging certain, certain messages to help, to get the body thinking in a different way and moving the needle in, different areas. But I think it's fascinating because we're, we're not taking a compound here. We're not, we're not interrupting a pathway. We're not blocking something or pushing something.
Freddie Kimmel (49:05.115)
Yeah. Yeah.
Nathalie Niddam (49:15.128)
We're simply sending a message. We need some help. And the body just go ahead.
Freddie Kimmel (49:17.851)
Yeah. Yeah, I mean, you know, pulled from the annals of bioregulatory medicine, we are hijacking a regulatory system within the body and using those innate attributes to create growth or healing or change or a shift in your internal environment. There's some of my favorite hacks. Some of my favorite hacks and we've never done on this podcast, we've never done a show on
BFR, blood flow restriction, katsu, all these things that fall into that container. But it's a fabulous tack. again, there's an amplified result of, again, using the Avacyn from microcapillary, the SOG, and the GLP. And again, it's great because I'm not loading up on 20 supplements to do this. I'm not taking a lifetime drug to do this. My hope is...
is that we're building, we're creating a terrain and we're changing the physiology. So I am always trying to like, well, how few can I get away with? Do I need to do it every day? Can I do it five days a week and two off? Now can I do three days a week and three off? Can I train the body to say, hey, good, we're safe. This is good. This is good. We built something new here. It's kind of the credit card or the asset class, which
Nathalie Niddam (50:21.058)
Mm-hmm. Mm.
Freddie Kimmel (50:38.603)
know, if can build muscle and we can add a couple pounds of muscle, it's like you have this mitochondrial bank that we're kind of working with now that we didn't have at the start of the endeavor. Yeah. Yes.
Nathalie Niddam (50:48.812)
Yeah. Yeah. Yeah. But you're writing that stimulus, right? You're exercising, you're moving the body, you're exposing yourself to light. You're doing all the things because the inputs, you know, I kind of laugh a little, I mean, I, and I get what they're trying to say, but I, I'm afraid of these exercise memetics or fasting memetics because I think they're fantastic as an added, as an added bonus. But what I'm, what I fear is that people will hear,
It's like fasting. it's like exercising. So now I don't need to exercise or I don't need to fast. And I wish that the word mimetic was replaced with amplifying or amplificator, or that was a really poor pronunciation of that word. amplificator, amplifier, amplifier, that would be it. Anyway, enhancer, right? Fasting enhancement, movement, exercise enhancement, because
Freddie Kimmel (51:35.683)
Amplificator. I bought it. I'll write that word out.
Nathalie Niddam (51:47.797)
Let us remember that this physical body needs physical stimulus to do what it needs to do. And there's no peptide, there's no supplement that's going to replace those foundational elements that you talked about at the beginning of the podcast that you teach about in your academy. Nothing can replace those because it's almost like you need the platform from which that your body can accept and make best use of those.
supplements if you're choosing to use them.
Freddie Kimmel (52:20.315)
Yeah. And there's nothing, I understand there are drug. Now we should, again, we haven't talked about this too. There's, I think there's a supplement out there called Mimeo. Is it Mimeo, which is a fasting, you know?
Nathalie Niddam (52:29.1)
Yeah. Yeah. It's a fascinating memetic. but because, know, maybe I was interested in, interesting in the sense that what they did is they, don't know if you've had him on,
Freddie Kimmel (52:39.025)
haven't had them on. However, can I tell a quick sidebar? Two years ago, I put up my old podcast gear on Facebook marketplace in Austin, Texas, and he pulled up in the driveway and bought it. Yeah. And before I even knew he was in wellness or had a supplement company, he bought my like some of my old mics and my amplifier.
Nathalie Niddam (52:41.9)
Yeah, tell the sidebar.
Nathalie Niddam (52:52.339)
you're playing. there it is.
Nathalie Niddam (52:59.788)
That's so cool. He's the nicest guy. looks like he's 12, 12 years old is what he looks like. and, and smart. So what that fasting mimetic is, is they, he studied fasting, people who are fasting, they studied the compounds that the body up regulates and releases in response to fasting and they put it in a pill. And so now we call this a fasting mimetic. I think it's a really great supplement.
Freddie Kimmel (53:01.745)
Nicest guy. Yes, he does look like he's 12. Yeah.
Freddie Kimmel (53:14.469)
Mm-hmm.
Nathalie Niddam (53:28.022)
And it's not going to replace fasting, right? It's not going to replace fasting because what is one of the key components of fasting is giving your body a break from food. And there's a lot of other things that happen other than the upper regulation of spermidine and all these other compounds. So can you, while you're fasting, either maybe shorter fast, take the supplement at the same time to kind of ramp up that, that those molecules to ramp up the benefits.
So that you don't have to fast for like five days or seven days. That's not in everybody's wheelhouse. Yeah. Heck yeah. You could even take it in the morning before you eat. let's say you're doing, you're taking a 15 hour break to avoid using the F word from dinner last night to your first meal of the day. Could it be helpful there? I think it would be a great thing to do there, but don't delude yourself into thinking that you can just pop those two pills and call it a day and turn your back on.
just not eating for 14 or 15 or 16 hours or 24 hours once a week or once a month or whatever the case may be.
Freddie Kimmel (54:33.105)
Yeah, today is my 24 hour fast, every Wednesday to Thursday, know, part of my lifestyle and then I'll do a three to five every three months. But again, there is a spiritual aspect of that going without. There is a mental fortitude. are things that you'll not get from, there's the community of fasting with, I'm doing it with Cynthia. She's doing a terrain coaching.
Nathalie Niddam (54:35.662)
Well, good luck.
Freddie Kimmel (55:01.051)
process right now to like mitigate her terrain after some like not great cell counts and a know partial mastectomy. So we're doing that now together you know and the process of cooking dinner at the end of that 24-hour window and breaking a fast together and the things that come up when you can't quell that emotional response with food and you think about what am I why do I keep walking to the refrigerator? What's that pattern? What's that loop?
Nathalie Niddam (55:16.014)
you
Nathalie Niddam (55:29.122)
Mm-hmm.
Freddie Kimmel (55:29.325)
Yeah, you're not going to get those from a pill. And I'm just such a huge, I'm so bullish on fasting. You know, again, I'll say all these things, the Avacyn, the GLP-2, those do not touch a five to seven day fast. They don't touch a five to seven day fast. In my experience, I could truly do all this because of the podcast, because of the workload, because of my choices. I don't have the luxury of doing that.
Nathalie Niddam (55:43.21)
No, no.
Freddie Kimmel (55:56.972)
all the time. So I just have to be a little more discerning and the technology allows me that I can have bigger windows when I choose to jump into that.
Nathalie Niddam (55:58.295)
And then...
Nathalie Niddam (56:04.77)
Yeah. Yeah. And let's acknowledge that at three to five to seven day fast is not accessible for everybody right now. Like people have to get to that point. so if you're listening to this and you're like, you know, I can't even skip them. Like people like my husband who he, his big thing is he does, he's never skipped a meal in his life. So my work with him is trying to feed him early enough the night before that he doesn't eat till the next morning. He won't eat at night after he's done dinner, but he will.
Freddie Kimmel (56:13.627)
That's right.
Nathalie Niddam (56:33.13)
He's just not a guy who will fast. You've got people who are metabolically not able to fast right now, or they're underweight. They shouldn't be fasting, whatever the case may be. So we're not saying that, you know, there's no judgment here, but there's just an acknowledgement that there's many benefits to this when you're ready for them that can be really, that can't be replaced by a pill.
Freddie Kimmel (56:46.961)
Mm-mm.
Freddie Kimmel (57:01.091)
It's some type of a bastardized stoic quote, but we don't rise to the level of our aspirations. We fall to the level of our basic training when under stress. this is more why I do it because I, because we never know what's going to happen in the world. I think it's a great skill to have in your back pocket. I want to, I want, I gotta be mindful of time of, of, your time. I want to talk about our next peptide topic and that's our
Nathalie Niddam (57:10.05)
Yeah, yeah.
Yeah.
Nathalie Niddam (57:19.918)
Freddie Kimmel (57:31.217)
which I've made some really good discovery and groundwork on. I was doing CJC. Is it at Bremmer Allen?
Nathalie Niddam (57:38.894)
and Epameralin. Yeah, CJC 1295 and Epameralin. Yeah.
Freddie Kimmel (57:42.93)
CJC 1295 and Upper Merlin. I was loving this. Absolutely loving it. I was like, wow, do I feel good? I felt so strong in the gym. So I was like, I don't feel like I can exhaust my, I'm like Superman in the gym. Probably did a bottle, did a month, two months, three months. All of a sudden, where I'm injecting my peptide, I was like, oh, that's itchy.
Nathalie Niddam (58:07.66)
Mm-hmm.
Nathalie Niddam (58:11.607)
Yeah.
Freddie Kimmel (58:11.779)
And then I was like, it looks like a mosquito bite. And then I was like, I have a well. now then, then like last week, I was like, I, I let myself scratch a little bit and I was like, I have never been this itchy in my life. Like I could, I had a night where I didn't sleep. It was crazy. I was like, what's happening? Is this new? Is this what changed in my physiology? But my body got to a point where it just said no.
Nathalie Niddam (58:14.734)
Mm-hmm.
Freddie Kimmel (58:42.073)
It said no. And so I had some longer conversations with some friends in the space and said, there's a reason for this. This is happening for a reason. There's like a myriad of possibilities, whether it's some type of an old co-infection, a history of Lyme. It could be your histamine response, could be mast cell activation. So I've gotten incredible relief with just doing
About a thousand milligrams of quercetin three times a day. Same with whole food vitamin C from Garden of Life. And then I've just been doing a little calamine lotion on the spot where I inject and pretty, pretty great. 90 % better. And that's just to stick with the GLP to stop the CJC. I've not tried that again. I'm going to give it a little bit.
Nathalie Niddam (59:19.822)
Mm-hmm.
Freddie Kimmel (59:34.947)
and just see but I would I called you I was like am I broken what happened and you said no so what what it happens
Nathalie Niddam (59:40.277)
No, it happens. It does happen. And you see it a lot with CJC. a lot. I, it's the exact same thing happened to me. Exact carbon copy. and unfortunately your immune system decides for, for reasons and, and for reasons that are not really fully clear.
to anyone, but the immune system decides it's no good, which is weird because we have CJC in our body. Like, I mean, you know, like it's bizarre.
Immune system says, no, not okay. Not happening. And in my case, I've never been able to go back to it. I see it. I experienced that with CJC. experienced some people can tolerate it from Morel. And without the CJC, I think what happens quite often though, is that people are using the combination of CJC and impamerelin. Once they've had that reaction, you can't, you almost, you can't separate them anymore to the body.
body. I tried it from Roland on its own. thought I was going to tear my head off. Like it was felt like my head was filled with ants and it happened within a minute of administering it. So those are on my no fly zone. Thymus and beta four is another one. Now thymus and beta four has a fragment to it that destabilizes mast cells, which is part of how it does the work that it does. And for most people who don't have a mast cell issue, it's a non-event.
And for some people who may have a little bit of an underlying mass, because I don't consider myself to have a mass cell issue, but apparently I do. so there's a little bit of an underlying imbalance there in my system. And so I can't use TB4, not, not my friend. and it can happen. This can happen with virtually any peptide and, and there's not a whole lot of clarity as to why, even BPC 157, like the.
Nathalie Niddam (01:01:32.631)
champion of the peptide world, which is naturally secreted as part of a bigger protein in the gut, in a very small portion of the population can create anxiety, anger, which makes no sense because on paper it balances the dopaminergic, serotonergic, and GABAergic centers of the brain. And for some subpopulation of people, it's a paradoxical reaction. Or they develop anhedonia, where they don't
care about anything anymore. So I think that for people who are going to use these compounds, you mentioned a journal a while ago, having a diary or a journal of some kind where you track how you feel when you're using these compounds is going to be very important. Right? So you, you have to become your own scientist.
Freddie Kimmel (01:02:15.217)
Mm-hmm.
Freddie Kimmel (01:02:25.317)
Mm-hmm.
Mm-hmm.
Nathalie Niddam (01:02:29.292)
We know that CJC and epimerelin can cause a transient increase in blood pressure and flushing when it's first administered. If it's transient and it goes in a couple of minutes, great. If you develop high blood pressure on an ongoing basis, you have a problem. You need to be tracking that before you've been living with it for three months. So it's, it's, you know, if you're going to play in this sandbox, then you kind of have to step up and be an adult and
Freddie Kimmel (01:02:47.781)
Mm-hmm.
Nathalie Niddam (01:02:58.496)
And be willing to monitor. How is your body responding to these things so that you get a heads up ahead of time? I don't know if you people like you and I would have had a warning beforehand, but I know for me, it was like, I actually, so funny. had the exact same response. I was like, I think I got a mosquito bite. And then, my God, I got another mosquito bite. And then you put it, you're like, wait, those mosquito bites. think those are exactly where I actually.
Freddie Kimmel (01:03:11.035)
Mm-hmm.
Nathalie Niddam (01:03:28.406)
injected these compounds and then you start to track. And then I had to put a bandaid on my mosquito bite because if my t-shirt rubbed against it, like it was off the charts itching like you. And then I, and I kept ignoring it because at the time way, way back, this is what the very beginning of when I got introduced to peptide, the person who gave them to me said, don't worry. Nothing can possibly go wrong. Never alluded to the fact that this could happen.
Freddie Kimmel (01:03:30.202)
Yeah.
Nathalie Niddam (01:03:56.323)
And it wasn't until one day I had injected my cocktail into my knee, like into the upper part of my knee, just cause it was a convenient injection site. And I woke up the next morning with a golf ball under the skin. And now I was like, okay, I actually think I need to pay attention here. And this became a major teaching moment for my community at the time and myself and started talking to doctors and other people who knew more about this stuff than I did. And sure enough, it's a thing.
Freddie Kimmel (01:04:05.777)
Mm-hmm.
Hmm.
Freddie Kimmel (01:04:14.843)
Yeah.
Freddie Kimmel (01:04:26.479)
Mm hmm. Yeah. Yeah, that histamine mass cell activation. There's also a strong neurological component there too. You know, this is kind of where I don't know if you've done much around the Dr. Gupta, the limbic system retraining, DNRS. This is that pathway, right? I do think there's... I haven't tested this out. I do think there's a way to work with this from the nervous system thought process limbic system side.
Nathalie Niddam (01:04:33.262)
Mm-hmm.
Nathalie Niddam (01:04:40.446)
Mm-hmm.
Nathalie Niddam (01:04:56.558)
possibly just, just have some good Benadryl on hand, just in case if, is that, cause that reaction can escalate, right? There's that, that reaction can absolutely escalate. And so you have to be mindful that, know, before we tell people, try to think your way out of it. And I think there's a lot to be said for that. mean, look at, Wim Hof. This is a man who was hospitalized for a study where they injected him with what? All kinds of toxins or something.
Freddie Kimmel (01:04:56.591)
that I'm
100%.
100%.
Freddie Kimmel (01:05:09.199)
Yeah.
Freddie Kimmel (01:05:24.132)
and endotoxin.
Nathalie Niddam (01:05:25.718)
Yeah. And endotoxin, they had him hooked up to every monitor known to mankind. And he was able through breath work, meditation, and to control his body's systemic response to that endotoxin. So what you talk about is 100 % possible. Is it accessible to most people? Probably not. So don't, don't be thinking you're going to do this and you know, sit and debrief for five minutes and get through it. And the most likely.
Freddie Kimmel (01:05:33.467)
Yeah.
Freddie Kimmel (01:05:46.349)
No. Probably not.
Nathalie Niddam (01:05:55.437)
Most of us don't have access to that unless we put in the work and gain access. So respect.
Freddie Kimmel (01:06:00.146)
That's right. That's right. Respect. Respect the body. Respect our physiology. Yeah, wild. I'll tell you, I got to tell this once. I can't remember if I've told it yet. One night, when I was kind of in my denial of itchiness phase, I went out and I was like, you know, I'm just going to go take a really hot, so I injected, I'm going to go take a really hot shower. And I went and just let turn the water on high. The hot water felt so good. And I started rubbing over the injection site.
like really rubbing it in. And I came back in and Cynthia was like, babe, you're like Santa Claus right now. I was like, I took a hot shower. She's like, no, you're red everywhere. And what I had done is I had pushed that CJC right into the bloodstream, not sub cue. And my heart rate went up to like, you know, like 89, you know, I'm like, I'm like right at like a 50 or a 54, pretty low heart rate.
Nathalie Niddam (01:06:39.171)
No.
Nathalie Niddam (01:06:47.539)
yeah.
Freddie Kimmel (01:06:58.925)
And it was like, she was like, can you breathe? we go to the house? I'm like, I can breathe. just very, I could, you you feel like that flush that, yeah, you're flush that nice and flush. I was like, okay, something's going on. Time to pause, time to do a little more research. But yeah, really, really wild. The point being to say that there are no, because people have said this on the podcast, there are no negative side effects is not, not in my experience, not valid now that I've
Nathalie Niddam (01:07:03.253)
Thank you.
Nathalie Niddam (01:07:08.034)
Like you're glowing.
Nathalie Niddam (01:07:27.777)
It's not true.
Freddie Kimmel (01:07:28.997)
It's not true. It's definitely something to be cautious with. The realm of precision medicine or, you know, concierge care. I think with a lot of these things, you do want some hand holding. I mean, I don't think I know. think you want to be cautious. You don't want to be the statistic of the person who...
Nathalie Niddam (01:07:48.121)
Well, and you want to understand what is your, what are your underlying issues, right? So if you're diabetic and, and, and you're going to be using a GLP one circling back to what we talked about earlier, you need to be working with a medical provider and you need to interview that person to know that they're actually aware of this stuff. Because here's what we know as many superstar, amazing doctors as there are out there. There are other doctors who
I don't think it's out of malice and maybe they're overwhelmed or they're too busy or it's not their area or whatever the case may be. Whether it's a doctor or a coach or a practitioner or whoever, if they haven't really dove into the stuff and are not aware, then you're, you're not getting the care that you need. the more metabolic imbalances you have going in, the more careful you have to be. So if you're going in to a coaching program,
and they're talking about nutrition and light and movement and all those things, amazing. But the minute you start bringing chemicals into the world, that, know, compounds like these into the picture, then understand, make sure that the person you're working with is aware and knows what to look out for.
Freddie Kimmel (01:09:01.359)
Yeah, brilliant, brilliant. I just have a couple follow up questions for you before we close this one down. I could interview you like every week. We'd always have fun stuff to talk about. And I know your plate is so full. Tell me it's full. Yeah, it's full. Everybody's...
Nathalie Niddam (01:09:16.654)
As is yours. Everybody's plate is full. We're fortunate. We live in abundance.
Freddie Kimmel (01:09:23.781)
me live in abundance. Tell me one of your favorite things you're doing right now that you're loving to optimize your health or your life.
Nathalie Niddam (01:09:33.858)
Mm.
Nathalie Niddam (01:09:41.901)
I'm loving the, I'm definitely, can I have two things from two different categories? So this, this, this, I will say, I was going to say my power plate, but I would say that this red light while I'm working on my computer has been an absolute game changer for me. And it doesn't have to be this one for you guys. Any red light in the room while you're working on your computer is going to help to.
Freddie Kimmel (01:09:46.181)
You can have four. Yeah.
Nathalie Niddam (01:10:07.944)
mitigate the negative effects of that blue light, which is a necessary evil. and I feel like my energy at the end of the day is way better. So that, and getting outside during the day, like you, I could be in here eight to 10 hours a day solid. Now the lucky thing I have is I have a dog who's aging and she can't go that long without going outside. So she forces me as grumpy as it makes me sometimes I'm in the middle of something and she's like,
Freddie Kimmel (01:10:12.315)
Mm-hmm.
Nathalie Niddam (01:10:37.646)
I go. I'm like, my God, you just went. I gotta go. Gets me out.
Freddie Kimmel (01:10:41.977)
Yeah. Yeah, amazing. Amazing. Outside time, red light. My other question for you in this ever evolving space, what are you doing? What are one or two tests that you're looking at to assess progress with all the peptides and the vibration plates and the brown gas and the hydrogen and everything?
Nathalie Niddam (01:11:07.406)
That's a good question. just this morning, there was a phlebotomist at my house. So definitely looking at regular blood work, because I think as much as it's not fancy schmancy, it's foundational information that is important to look at. It's so funny you asked this, like in the last 24 hours, I've mailed two test kits and had a phlebotomist at my house.
Freddie Kimmel (01:11:18.449)
Mm-hmm.
Freddie Kimmel (01:11:26.097)
Mmm.
Freddie Kimmel (01:11:36.241)
Mm-hmm.
Nathalie Niddam (01:11:36.973)
The two test kits I've mailed, one is the therium metabolomics test. Yeah, it's fantastic. I think that is, and it's evolving, right? It's a very advanced test and know that when you're jumping on board with these guys, you're, riding the wave with them. You're learning with them as they learn. and then the other one that I don't do as often, maybe as I used to is the true diagnostic, a biological age test.
Freddie Kimmel (01:11:42.865)
I got that one done, Starris. I've done one.
Freddie Kimmel (01:11:48.122)
Yes.
Freddie Kimmel (01:11:57.713)
That's right.
Freddie Kimmel (01:12:04.102)
Mm-hmm.
Nathalie Niddam (01:12:07.01)
cause I, I love it. think it's a great metric. And at the same time, I sort of have some mixed feelings about it. I'm not always, I don't always feel that it's as quite as solid as I repeatable, say, as I would like. And therium does give us a biological age as well. So
Freddie Kimmel (01:12:13.457)
Mm-hmm.
Nathalie Niddam (01:12:27.478)
And I just want to say that I'm not doing my biological age test so I can brag that I'm eight, 10, 12, 20 years younger than my chronological age, because I think that these tests are so, it's what they're measuring is so amorphous. But what I do want to know is, is my pace of aging accelerating? Is it staying the same? Is it slowing down? Am I, am I burning my engine out as I go? And sometimes you can do that just from.
Freddie Kimmel (01:12:49.787)
Mm-hmm.
Freddie Kimmel (01:12:53.497)
Mm-hmm. Mm-hmm.
Nathalie Niddam (01:12:57.112)
from too much stimulus. The first therium test I did, they asked me to back down on a number of supplements I was taking because it was too many inputs for my body. Right? So these, think that the regular blood work obviously is a must, but the therium to me is one of the tests right now that I'm really passionate about because I feel that it, the way that it looks at what's happening as a
Freddie Kimmel (01:13:05.201)
Hmm.
Nathalie Niddam (01:13:24.226)
and in the pathways, what's happening is a downstream effect of the inputs you're putting into your body. It's very powerful insight.
Freddie Kimmel (01:13:29.147)
Mm-hmm.
amazing. At this time in your life, have you done any work with stem cells or exosomes?
Nathalie Niddam (01:13:42.158)
Sure.
Freddie Kimmel (01:13:45.125)
And if you had to choose one, stem cells or exosomes, which would you pick?
Nathalie Niddam (01:13:48.65)
I think it would depend on what I was trying to do, my friend. so right now the, so I've done a couple of exosome IVs, which were interesting. I don't know that I, I noticed too much from them. I've used my own V cells, which is a very small population of STEM cells in the body. use them in a regenerative injection in my right knee, which worked quite well.
Freddie Kimmel (01:13:51.259)
Yeah.
Freddie Kimmel (01:14:03.942)
Mm-hmm.
Nathalie Niddam (01:14:17.572)
I've also used them in my, for facial rejuvenation and, know, hard to know how well that worked because we would have to take another me and not do it and see what I would have looked like if I didn't do it. Hard to say. and then just recently I, I, there's a company in Toronto called Acorn biolabs. I, I released a podcast with them four years ago and four years ago, they were just starting the process of.
Freddie Kimmel (01:14:29.489)
That's right.
Nathalie Niddam (01:14:46.958)
harvesting people's hair follicles and cryogenically preserving them because in those hair follicles are stem cells, fibroblasts, all kinds of different growth factors. And Drew Taylor, the scientist who started this company, was like, we are going to be able to use those for joint regeneration, for healing, for facial rejuvenation, the whole nine yards. And so right now I was delivered two weeks ago my own secretome.
from 10 of those hair follicles that were pulled out of the freezer and they're being micro-needled into my face, into my hairline. And I know that there's doctors out there using them off label for other purposes. So we will get more information over time about what these can be used for. So now you get to see my actual face without the red light on it. So I've had my first micro-needling done with that. So I think that...
Freddie Kimmel (01:15:29.051)
Mm-hmm.
Nathalie Niddam (01:15:44.674)
You know, the exosome stem cell regenerative space is, as we all know, is exploding. I love these modalities like the V cells and the acorn biolabs, the hair follicle, because we're using our own material. And we're bringing it back to our body to do what it needs to do. Not that I'm saying that there's no value in exosomes that come from somewhere else or...
Freddie Kimmel (01:16:01.851)
Mm-hmm.
Nathalie Niddam (01:16:12.256)
stem cells, some, I know people whose entire existence was changed by stem cells. I just think if you're going to look at these things, understand what problem you're trying to solve and explore what would be the best for you.
Freddie Kimmel (01:16:14.875)
Mm-hmm.
Freddie Kimmel (01:16:26.085)
Beautiful. Beautiful words, beautiful insight. So appreciate you doing this. Excited to release this into the world.
Nathalie Niddam (01:16:31.362)
Thank you. Thank you for having me. Yeah, well, it's always a pleasure to be in your sphere, my friend. Thank you so much.
Freddie Kimmel (01:16:37.743)
Yes, big love.
Nathalie Niddam (01:16:40.249)
back at you.
