Spermidine and Extending Lifespan with Don Moxley

This episode focuses on the quality of life extension and vitality as he discusses how Spermidine Life came to be. We’ll delve into how the supplement works in our body Don shares the autophagy process, why spermidine is an essential nutrient, and how it improves our overall system to reprogram and repair.

On a side note, don’t miss this chance to attend the Biohacking Congress happening at Miami on October 16 - 17 as there’ll be speakers that’ll talk about biohacking, health companies with products and solutions for health optimization, and more! Use the code HACK50 to get 50% off your tickets!

Episode Highlights

4:00 Podcast as an educational material to digest information

6:43 On discovering spermidine and its role in the body

10:23 How autophagy works and why its triggered by calorie restriction

14:42 How SpermidineLife enhances good aging and long healthier life

18:11 Key activities for cellular growth and autophagy cleaning

26:14 SpermidineLife as a supplement, not a substitute

30:46 His studies on taking SpermidineLife while fasting

33:09 The right approach when recommending SpermidineLife

36:51 Noticeable changes on cells and the body when intaking SpermidineLife

40:07 Health hacks to live healthily and the challenge to achieve it

48:51 Why being beautifully broken means learning from mistakes

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EPISODE TRANSCRIPT

Freddie Kimmel and Don Moxley (00:03.32)
Welcome to the Beautifully Broken Podcast. I'm your host, Freddie Kimmel, and on this show we explore the survivor's journey, practitioners making a difference, and the therapeutic treatments and transformational technology that allow the body to heal itself. Witness the inspiration we gain by navigating the human experience with grace, humility, and a healthy dose of mistakes. Because part of being human is being beautifully broken.

Freddie Kimmel and Don Moxley (00:37.359)
Through my healing journey, I've become increasingly aware of the way environmental toxicity affects my body. In the past, I've tested high for mercury, lead, cadmium, glyphosate, and mycotoxins from mold. I've experienced this as fatigue, full-body neuralgia, and brain fog.

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Freddie Kimmel and Don Moxley (02:17.315)
Ladies and gentlemen, we're about to get on the roller coaster ride of wellness. But before we do, before we talk to Don Moxley from Longevity Labs, and we talk about these incredible new advancements with products like Spermity and Life, we are gonna talk about an opportunity for you and me to get a real-time hug. Who's ready for a real-time hug? Well, this could possibly happen at the Biohacking Congress in Miami, October 16th through the 17th.

and you can go and you can actually get through the podcast 50 % off your tickets. So I'm going to tell you about that code. It's hack50, H-A-C-K-5-0 for the Biohacking Congress. And it is going to be an incredible weekend with 25 speakers in the topic of biohacking, 20 health companies plus

with new products, digital health services, solutions for your health optimization. And we can be together live in Miami, October 16th through the 17th with code hack 50 for 50 % off your tickets. That's my small announcement. We'll talk about it more in the subsequent episodes coming in these next few weeks. I love you so much. Let's get started. and gentlemen, welcome to the beautifully broken podcast as we cruise past episode 100.

I'm going to keep saying it out loud because it feels so good. I have the honor of a very special guest today. have Don Moxley, Director of Applied Science at Longevity Labs. And we are going to talk about that very topic, the quality of life extension and vitality. Don, welcome to the show. Thanks. I'm excited to be here. I consider it an honor to be with you. Thank you so much. Thank you so much. I always consider it an honor that someone would take an hour out of their day.

to connect with another human being on a topic that they're passionate about. know how busy we are and we're overtaxed and over scheduled and traveling all over the world. And for me, I said this a couple episodes ago, some of the most valuable way to digest information has been through this format of podcasting. What's been your experience with getting information this way? Well, I completely agree. am so.

Freddie Kimmel and Don Moxley (04:28.887)
To give you a little bit of background myself is I grew up in a small country town in a little town called Barnesville, in Eastern Ohio and was labeled as vocational by the education system. And listen, I grew up on a farm. can burn steel together. I can make things work. I mean, I'm good at that. I think abstractly pretty well, but I was a decent high school wrestler and my parents were basically insisted that you're going to college. And I was going to go study agriculture. So you go to Ohio state.

which was the only real agricultural school in Ohio and walked on the wrestling team there. So I got through my undergraduate and then as I was finishing up my undergraduate, my younger brother was coming to heat. My younger brother was a very talented football player, big kid, six foot nine, very talented athlete. And he came in and started testing and they identified him as dyslexic. And I looked at that and I go, well, I think I've got some of that myself.

got the testing done myself and the dyslexia is interesting because if I have to sit down and read a book, it's a job. I mean, it's work for me, but I kept developing and I wound up, I finished up my graduate, I finished up my master's degree and I've spent 25 of the last 35 years as either an associate or an adjunct professor teaching the exercise science. And one of my gigs is I had an hour and a half drive to the small college in Western Ohio and I started with audible.

And I had a group of podcasts and I just absolutely consumed. mean, I just digested information. And what I learned about myself is that if I listen to a book, I retain about 70 % on the first pass. If I listen to it and read it simultaneously. And when I'm listening, when you do this well enough, I usually listen at either 2x. When I'm really dialed in, I can listen at 3x speed.

But I can listen to three X speed and read at the same time and consume a hundred percent of the book and retain a hundred percent. So this audible format is very efficient and learning and in particular for me. Incredible. I think that's our recipe for gold here on this episode. I want to jump in and just talk about, said, you know, you're a chief scientific officer. We mentioned longevity and vitality.

Freddie Kimmel and Don Moxley (06:53.027)
I think that's a great segue into our topic. A lot of my social media feed lately has been filled with a dialogue about a product called spermadine life. And it keeps coming up as a anti-aging vitality, the ability of the, guess I would say almost like a trigger for the immune system to function as intended. And I'm just kind of interested. It seems like you're the person to go to for the good information about this product.

Well, you know, it's that we're excited to work. Listen, sperm and life is a flagship product for our company, and we're excited about it. And I'll tell you, Freddie, that a year and a half ago, I had never heard the word sperm and I was casually attuned to a term called autophagy. I'd heard it. I had not studied it. And I was working. I actually left sports science. I was working as a sports scientist of Ohio State. I left that to go work in the cannabis industry.

I was doing a similar role with a medical cannabis company in Florida and was invited to explore this company. when I started to do the deep dive into this, it's been amazing because, listen, when we look at nutrition and we look at dietary programs, one of the key, you deal with what's called nutrients. We know vitamin C is an essential vitamin.

because if you don't take it from exogenous sources, you develop scurvy. This is how we figured this out. And literally when you look at nutrients, you can trace them back to there was a condition that developed because, and that was resolved when you supplied this nutrient exogenously. Well, as we start to look at aging and we just listen, there's a term, this term autophagy. They just awarded a Nobel prize in 2017.

to the researcher that very effectively described the processes of autophagy. That's how new this stuff is. And when we start looking at nutrients, as we begin to understand autophagy, we start to identify this molecule that's a key trigger in the autophagy process. And that is this molecule called sperminine. And when we start taking a look at it, sperminine, the evidence is becoming increasingly clear. It declines with age, which in turn results in a decline in autophagy.

Freddie Kimmel and Don Moxley (09:18.1)
which at that point, I believe that the nutrition textbooks, a decade for now, will teach autophagy as a nutritional strategy, as a nutritional benefit that is triggered with calorie restrictions. So nutrition textbooks will eventually get to not what should you eat, but it'll eventually include when you should not eat and understanding that there is this biological process

that's key to cardiovascular health, that's key to the prevention of the development of dementia. Think that, let alone say that three times. And we look at myocardial performance, we look at neural performance, we look at immune performance. Autophagy is very important. And what we see is that sperminine is one of the molecules that's a trigger for autophagy. Incredible.

I also think it's very, I think it's humorous to listen to all the different experts in the world, say autophagy or autophagy. There's lots of words that people have their own little flavor on. Can you just for the audience, could you break down autophagy for us? So autophagy is a intracellular process. So what happens is, and listen, we really started to recognize the value of calorie restriction in the mid, in the mid 1950s. there was a researcher Cornell, Clive McKay,

was struggling with funding for his lab and he had a lot of mice in his lab and he had to make a choice. He couldn't feed them all. He just didn't have the budget to do it. So he started feeding a group of mice half of their diet and took notes on this. And what he found is that that group of mice that were calorie restricted actually were aging better than the mice that were getting full feed.

And this was one of the first signs when we start taking a look at longevity and experimental longevity controls, calorie restriction is one of the only ones that we see universally applied. so when we figure out, so why does eating less lead to better health? Well, what we've been able to figure out is when we look at this, we have a cellular process called autophagy. it's when your body is, when your cells are working correctly,

Freddie Kimmel and Don Moxley (11:35.944)
they're getting a signal to go ahead and grow and reproduce. And part of the growth process is that we stimulate a molecule in our cell called mTOR. And this tells the cell to make proteins. But when you make proteins, they're not all perfect. But if you don't have a perfect protein, it doesn't get to go into the system and work. It actually just sits there in the cell. And if you do this too much, the cell gets overwhelmed with old organelles and old, what we call long-lived proteins.

Well, in the process of autophagy, when we calorie restrict, the cells says, hey, there's not enough energy coming in from the outside. Let's go ahead and clean up our act and let's go into ourselves and find the parts that aren't doing anything and let's digest those and put their subparts back into service. So essentially autophagy is this process of cellular renewal, cellular cleaning that is typically triggered through calorie restriction.

But with research, what we've found is that there are exogenous nutrients that help trigger the autophagy process. Yeah. Incredible. I love that deep dive and the explanation. I also tell people it's like Pac-Man's your body goes back to your body goes into Pac-Man. You said misfolded proteins are proteins have a can get into this bad pattern. You know, I was just reading an article, not to take us off topic, but about zombie deer in Austin, Texas.

really? Yeah. Yeah. That they're seeing, they were seeing some of these deer where they're having these areas of their body kind of decay. They, and is this, there's some of this, is that called like a prion? Is that like a misfolded protein that would result in like decaying of a certain area of the body was kind of dead? Well, listen, I think you're playing in the same ballpark. It's a little different game when you're looking at pre-ons and pre-ons are the precursor to a condition that we term mad cow disease.

And these are bad proteins that get passed from animal to animal. And when they get in your system, they just create a lot of problems. again, similar ballpark, different game. we look, listen, the body's an amazing thing. DNA is an incredible, it's an incredible process. And when your body starts making protein, it recruits the nucleotides from DNA to tell

Freddie Kimmel and Don Moxley (13:59.784)
the ribosome, the part of your cell that makes protein, it says, here's the proteins you need to make. Here's the amino acids you need to bolt together to make a protein that we need for a particular need, whether it's hair, skin, nails, muscle, whatever. Well, sometimes one of those nucleotides does not print correctly. One of those amino acids does not join. And every time that amino acid adds, there's a particular fold that is creating in the protein. And if that fold's not right, the protein can't go into service.

So that's the pre on again, it's in a similar place. It's a little different game. Yeah. So just everybody bookmark zombie deer. We'll be back with a different podcast episode on that and we'll do a little deep dive. how, how is spermadine or this product you're working on with, with longevity labs and you guys do have a product in the market. How is this coming in and being of service to this process of autophagy or another aspect of anti-aging? Well,

So we go back to autophagy as a longevity promoter that the better job you do, the evidence is getting pretty clear here that the better job we do of clearing these long lived proteins that are no longer productive or organelles, you, there's a, so we can digest old mitochondria. So mitochondria will wear out over time and it's important to get them out of your cell.

so that the good mitochondria reproduce and redevelop and keep your energy production up. So when we look at the top of the G, it's the digestion of long-lived proteins and organelles, particularly the mitochondria. We even have a term that's called mitophagy. So it's the top of the G of mitochondria because it's so important that lead to this cellular renewal process. And when we look at the effects of aging or poor age, listen, I don't like the term anti-aging.

because the minute your parents did the deed and the sperm hit the egg and created that zygote, you started aging. Aging is a good thing. And when you stop aging, it's a bad thing. So I don't like anti-aging. like good aging and living long, healthy, you know, with an extended health span. So when you have this increased autophagy process, when we look at blue zones,

Freddie Kimmel and Don Moxley (16:21.404)
We look at populations that have good autophagetic processes going on. So they're not developing the byproducts of living long, the diseases that come with aging. given this nutritional supplement or intervention, what are some of the downstream effects of beneficial effects of using sperm in as a supplement? Well, what we're starting to see is that uptick of autophagy that comes, you know, returning autophagy to levels.

similar to what you had in youth. Because what we know about spermity is that you're born at a certain level. It peaks about 12 days after that. So mother's milk is very, high in spermity. And those levels really kick up because you've got so much cellular process going on with growth. You want to have those systems very high, very young. But then it starts to decline from there on out. And what we find is that people who live well into their 90s and centurions

have spermidine levels similar to those in their 30s and 40s. So those that live long well look like those who are in youth or 30s and 40s, we're still in reproductive phases of our life, which is the very juvinescent phase of our life. And so it's this associated spermidine level and the associated autophagy levels that come with that, that help that when we start looking at the diseases of aging,

Many, most of them are related to a decline in the cells ability to reproduce, to defend itself against infection, to do the things that we have with youth. that, I, I'm not quite as elegant as I would like there. No, that's great. I think, I think what I want to follow with is, you know, aging is going to present differently in different people. And one of the metrics, this is kind of sounds so bad and I hope

Anybody from my high school class doesn't think I'm throwing them under the bus, but whenever I am around, you know, you'll be around somebody you graduated high school with, right? Right. And it's like the ultimate like measuring stick. know this sounds terrible. Compare and despair. Exactly what you're talking about. But I'll notice because even though going through a lot of intense medical stuff, part of my last, I don't know, what is that? We're 2000, 2020, 2021. That sounds so wild to me, but

Freddie Kimmel and Don Moxley (18:47.076)
I'm talking, I started kind of in this health stuff about 2008. You know, so I've got a good little track record of an elite diet, really clean water, like the red light therapy, magnetism, all the things, right? And so if I show up next to in Wegmans grocery store where I grew up, was the big grocery store. Love Wegmans. Love Wegmans. Next to somebody from my high school class, not everybody, but generally I look like I've aged less.

you know, graduated high school in 1990. I'm gonna out myself 1996 just turned 43. And so I'm like, okay, something different. There's something different that I maybe it's genetics or maybe it's lifestyle choices where I'm aging at a different rate. As far as spermadine goes, how would let's say you have somebody that's going to in your family and they're taking this for autophagy.

How does the exterior experience spermatine? You know, we could say autophagy on the inside. What happens to the outside of a Freddie or a Melvin or a Sarah? Sure. We can let's talk about that. Listen, I'm considerably older than you are. I graduated from Barnesville high school in 1980. So I, I currently am finishing the last year of my sixth decade of life. Wow. Wait. And for everybody at home, you really don't have wrinkles.

Let's not go there, but I'll tell you. So in our little town, the little town I live in called Granville, Ohio, we have this wonderful Fourth of July parade and celebration that we do in Granville. And I watched and so I'm watching the parade and the float of the 1980 graduates came through. And I thought, damn, I'm doing pretty good compared to that. So there are multiple elements that contribute to yourselves ability to reproduce

to have good longevity, good lifespan, good health span. you know, so when we talk about the key elements of healthy age, listen, one of the big, and we can't let, I'm gonna step away from sperminine for just a second. But when we start talking about the elements of healthy aging, you cannot ignore the value of movement, of exercise in long life. When we start looking at exercise,

Freddie Kimmel and Don Moxley (21:03.674)
There is a contribution to the process of it. There's a pathway to autophagy from exercise. So exercise is the key element, both in cellular growth and in autophagy cleaning. I call it the four big rocks in the jar. If you're familiar, Stephen Covey in the seven habits of highly effective people, he talks about if you need to get a pile of rock, sand and gravel in a jar, you have to put the rocks in first and then you put the gravel around and the sand flows in.

So you got to follow on what are the big rocks? And I think the big rocks of longevity, you cannot ignore exercise. Okay, it's critical. Now, listen, I'm an exercise physiologist. I've been teaching the exercise sciences for 35 years now. I try and make it part of my life. And so if I'm doing something well, I'm exercising. This is one of our challenges to your listeners is, so many people exercise because they want to lose weight, okay? But a picture of a scale

hanging on someone's wall does not exist. Okay. No one defines themselves by the number on a scale. And I think it's important to figure out how you define yourself and what you're living for. So exercise is the first thing you should exercise not to lose weight, throw the scale away, be done with that. You exercise to live long and healthy. What we call to thrive in your third third of life. You spend your first third of life learning.

You spend your second third of life in service to others, either your family or your work or things like that. But there's a part, you my wife and I are getting my daughter's going to live with us for another year right now. And then we start to enter our third third. My response and my direct responsibility as a parent with a child, my household is ending. But it's that third third that's our third. That's my third. I'm investing in me and I want that to go as long as I can. So the ability to have and thrive in the third third

Movement is critical. It's critical. So exercise. That's why it's there. The second rock in the jar that I talk about is getting your food from clean sources. I don't like going down vegan or carnivore or things like that. Just make sure that the food that you're eating was able to reproduce in its last phase. You know, it's coming straight to your plate from a living source, you know, and not highly processed. So fresh food is important. The third rock in the jar is sleep.

Freddie Kimmel and Don Moxley (23:28.718)
It's part of the stress management cycle. And in the absence of sleep, you're screwed. We see this in high performance athletes. This follows through into longevity. But the fourth rock in the jar is light. And this is becoming even more as we see the emergence of the value of some of these red light hacks. Listen, I have a juve unit in my house. And if you would have told me it was going to be as effective as it is, I would have laughed at you. It's incredible. And understanding light.

understanding these things going. So my four big rocks are exercise, fresh food, sleep and light. Now, the last part of this, though, is you have to look at the jar. The jar is your purpose. What is your purpose in life? And I think that's really important because in the absence of the jar, you've got no place to put the rocks. And so kind of on a long tangent here. So I'm going to come back to it. You cannot when we look at exercise, food, sleep and light.

Ironically, there is some connection to all of those into the autophagous cellular performance pathways, either mTOR developing or autophagy generating. These are critical. it's that yin and yang that comes with both of those that's so critical to life. Hi friends. I hope you're loving the show. Let's take a quick break to hear a word from our sponsors.

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Freddie Kimmel and Don Moxley (25:49.38)
So check out light path led.com and use code beautifully broken all lowercase for a 10 % discount in the checkout. The inventor and founder, Scott Kennedy is a true gem of a human being and stands behind every light that he sells. This is a beautifully broken podcast stamp of approval, five stars. Now let's get back to the show. Okay. I'll jump off my soap box for a minute. like that. I like that idea that, you know, I talk about the container all the time.

The often that I've used lately is because, you we're in such a unique world here and it's so divided, which I mentioned before, it's like you're seeing people, especially on social media, less in life and real person. But I always give the example of walking down the street. If somebody bumps me and I have a cup of coffee, coffee spills out, you know, and I feel like that's the same with these egos that we care around. It's like when someone pushes me energetically, what spills out.

It's hate and fear and loathing towards the human experience or it's joy and it's empathy and it's understanding. it's like, what I cultivate in that container, I love that example of the glass. It's like, yes, build the sleep and the longevity hacks and the exercise and the sperm and at the end of the day, if the container is not of great quality, it's all for it's pretty empty, right? You got to have that purpose. And listen, it's clear when we look at research, when we look at longevity research, people who live long have purpose and

Constantly finding that listen, how many examples do we see where someone retires and three days later? They're dead. This happens way too often But you know to go back to your original question. I don't consider sperm and I'm a rock It is gravel. It is maybe sand Mm-hmm, but consuming sperm and I'm without exercise eating highly processed food with shitty sleep and bad light You know what you're throwing your money away, but

what we're starting to see was something like sperm and I and when we started taking a look at biohacking, what is biohacking? Once identifying those things, listen, our genetics, our genetics were established depending on how you either any a hundred thousand years ago to a million years ago, depending on who you want to look at. And then the absence and in our genetics, the homo sapiens genetics were successful over Neanderthal primarily because of our ability to adapt. And this is what drive it now.

Freddie Kimmel and Don Moxley (28:10.817)
Unfortunately, we live in a society, we live in conditions where we're not forced to adapt. I'm in a hotel room right now in Southern California, and I've got a thermostat on the wall that the temperature is going to be maintained within between 70 and 72 and 68 degrees. And if it drops, if all of a sudden the temperature goes above 72, my body's going to say, hey, what's going on here? Well, that signal to change is important.

We don't move enough because we live in rooms with flat floors and we sit in chairs so we don't have to squat. We don't have to pick up heavy things. We don't have to sprint to save our lives. We don't have to sprint to get food. So that's that movement part of the rocks. And the challenge is, are we getting the necessary components to feed our DNA to be successful?

This is where vitamins come into play. This is where essential nutrients come into play. And what we're just identifying is spermine is an essential nutrient for the process of autophagy that becomes more important as you age. And you know what, if you get it from natural food sources, good on you. Okay. What we're finding is that's hard to do. It's one of those nutrients that's been bleached out over time. If you're Japanese and you consume NATO on a regular basis,

you're probably getting all the spermidine you need. we're finding, you we get ours from wheat germ, a wheat germ extract is produced in central Europe. We're struggling. We'd love to make spermidine in the States, but we're struggling to find wheat sources that are spermidine rich enough that we can even get into the process, let alone, you know, the issues with glyphosate as that comes into play. But it's one of those key nutrients that you've got to bring in. It's gravel in the jar.

So one of the things, again, I'm trying to go back and answer your question. One of the things you notice when you take sperminine is one of the first changes our customers report is they see a change in their hair, skin, and nails. Hair grows better, skin becomes nicer, nails grow faster. My nails, I noticed right off the bat, takes about three to four weeks. The older you are, the faster you feel it, which makes sense with sperminine decreasing with age.

Freddie Kimmel and Don Moxley (30:25.813)
But what we know is this autophagy process triggers an epithelial stem cell process in the skin. And remember, your nails and your hair are extension of skin cells. So as you see the stemminess improve in those cells, you see an improvement in those particular areas. So that's one of the first things that people notice. Yeah, I

You know, it's funny, I've been a huge, huge believer of fasting for years and years and years. And there's so much great research on, you know, some of my favorite books, the metabolic approach to cancer, which I quote often, we talk about the doing targeted a little bit on the longer side, sometimes a one and three day fast, sometimes a seven to 10 day fast once or twice a year, something I've always practiced. Now, if I'm already fasting, if I'm already putting my body into autophagy, or maybe it's intermittent fasting,

would my body benefit from incorporating something like spermadine? We think so. So spermadine by itself will not replace the value of a good fast. Okay. It'll enhance both. Listen, autophagy is a cellular process that's present at all times. As you reduce calories, listen at night, as you reduce the food calories coming in, you'll reduce the signaling.

of insulin and IGF. And with the reduction of that signaling, you see an uptick of autophagy. Now, it may not be long enough to get the real benefit or to prevent the onset of poor dietary habits or exercise habits or things like that, but it's certainly there. What we're seeing is that as you increase, we know sperminine levels decrease with age. We know that the research is pretty solid there. So if you are fasting, if you are an old faster,

and you have a decrease in sperm and I'm increasing sperm and I will increase the effectiveness of fasting. Does that make sense? Yeah. That's great. So it's, one of those key mechanisms in the autophagy process. And listen, we're again, they just gave a Nobel prize in 17 for describing the top of G.

Freddie Kimmel and Don Moxley (32:31.689)
The research, know, Dr. Frank Medeo and Dr. Tobias Eisenberg, they're two of our founders. They're at the University of Gratz and they're doing amazing work. This is cutting edge stuff. Shortly after they figured out vitamin C, you know, someone figured out, hey, we give lines that prevent scurvy. What is it in lines that makes a difference? Well, it's vitamin C. Well, roughly we're at that phase right now with things like spermina.

Yeah, it's fascinating how these discoveries naturally come from kind of mimicking the laws of nature, how they present themselves. love that. I know, I know. Imagine there was some lessons out there. I want to go back to, again, I think it's valuable to see where the rubber meets the road, especially I'm always thinking about how do I get my family members to consider this or people in my community that would kind of be like, you're doing what with a what names with a sperm in the name? Yeah.

I remember there was a health coach I worked with. Actually, she was a nurse practitioner in New York City. I was really lost and she had me doing wheat germ capsules, breaking them open and spreading them on my scars. yeah, I mean, this was like 10 years ago, 11 years ago. And she was telling me, she's like, this is really going to help the tissue regeneration. It did. It helped the quality or the elasticity of those skin cells. So it's funny. I've kind of touched on this a couple of different times.

Again, if you're looking at your community and saying, Hey guys, this is a good thing to entertain. How would you start that conversation and kind of, kind of make that case to a family member? Yeah, we call it the banana peel part of the, of the conversation. Right. And the language I've learned is this. Everyone asks, so what do you know? I work for a company called longevity labs. And what do you know? It's a nutritional supplement that we have found that really helps with a process called autophagy. What we know and what we found in research is that.

There is a molecule that's in every cell of your body, men, women, plants, and animals, and that molecule declines with age. And this molecule is critical in the development of this process called autophagy, the cellular cleaning process, that when autophagy is at a high level, you don't see the onset of many of the age-related diseases. And by this time in the conversation, they're like, I get it. And they'll say, so the molecule is called spermini.

Freddie Kimmel and Don Moxley (34:51.497)
It's a little molecule that's in every cell. We get it from wheat germ extract, but it's in a lot of other plants. We've known about it for hundreds of years. We're just starting to understand how it works though. Great. A question that just came up for me, a trigger word because I've worked so hard to get wheat out of my diet. What would you say to someone who is gluten challenged or gluten sensitive? You've got to be careful. So our testing shows that we do have a very, very, small amount of gluten in our product.

We have many celiac patients who are using the product and telling us that they're doing it, that it's working fine. But my wife has celiacs and I have held her hair back way too many times when she has gotten polluted. that is just, listen, it's an awful situation when it happens. But we have 1.3 milligrams of gluten per serving. Now to put this in perspective,

The celiacs association says you want to keep your gluten consumption below 10 to 50 milligrams a day. 10 to 50, we have 1.3. To be considered gluten free, we have to be below 20 parts per million. We're about 50 times above that at our current concentration. But we have people who saying, they figure out the math, they break their capsule open into a smoothie.

then all of a sudden you're below 20 parts per million. But listen, you have to own your own situation. My wife does this and she's tried it. She did not have a celiac response from it. We have some people that have. if you have, bless you. I'm sorry. We're working hard to try and reduce that. When you look at sperminine supplements on the market, we are an order of magnitude lower in our gluten content.

So when we look at this, this is something we take a lot of pride in when we work on, but you've got, listen, you've got to be careful if you have celiacs or if you're very gluten sensitive, it's a challenge. Yeah. Let's talk about the market for a second. I'm sure you're not the only company out there with a spermidine product. You're not where the original, but we're not the only. And so as a consumer, when I'm out there looking, I'm saying, Hey, kind of, you know, I'm going to, I'm going to try this.

Freddie Kimmel and Don Moxley (37:06.753)
I'm going to give it, I'm going to give it two months, three months, four months and see how my body responds to how I feel. Is there anything you tell people to look out for? you, do you have a first and foremost recommendation? mean, again, grain of salt, you work with this company, but just go ahead and give us your honest Johnny on the street opinion. Listen, I send product. We, have a lot of people that work with it. And if you purchase sperm and I in lights from our website,

you'll get put into a string that will invite you to have a phone call with someone from the company. And I'm one of the people that takes that phone call. And so I've spoken with hundreds of our customers. And when we talk about it, the customers tell us there's kind of three things you have to pay attention to that most people will notice this change in hair, skin and nails within the first three to five weeks. A lot of people indicate that they notice a change in their sleep pattern.

One of the first things I noticed when I first started using sperminine was the uptick in lucid dreaming. It was really cool. you know, listen, am I a good enough scientist to latch onto that? No, but you know what? We know sperminine crosses the blood brain barrier. We have research that shows that. We know that sperminine content, increased sperminine content in the diet improves cognition.

in older people, we know that it increases hippocampal thickness, which is your memory. You know, it's your it's your random access memory in your brain. We know increased sperm and content helps with the Alzheimer's parts of the brain that are threatened by Alzheimer's. So we see an improvement in cortical thickness there. So we know something's going on above the neck below the neck. The first thing you notice is this hair, skin and nails now. And we have some people that call and say, listen, I just don't feel it.

And you know, may fall in that category. may not, you may not feel improved autophagy, but we do have a fairly significant group that calls us and says, I didn't feel it. I stopped taking it. And about two weeks later, I noticed that difference. So the onset can be very gradual. Yeah. I mean, that sounds in alignment with most other, it's hard to feel a supplement.

Freddie Kimmel and Don Moxley (39:27.169)
You know what mean? It depends on how sensitive you are and it depends on how in tune with your body you are. So that's, it's definitely something I'm attuned to. depends where the supplements hitting, you know, if this supplement is lighting up a receptor on your nervous system, if it's caffeine, nicotine or cocaine, yeah, you feel that pretty quick because it's lighting up a receptor on your, on your central nervous system. If it's THC, THC, ACBD, any of the cannabinoids.

That's locking onto a receptor in the central nervous system. When we start looking at things like sperm and I, an NAD or any of the nicotinamide derivatives, you know, that's floating down into the cell and acting differently. Yeah. I would concur with that. I would say the other thing I really want to get at, Don, is let's say you have a, um, kind of visualize your most beloved one or two family members. You know, if you had a magic wand and you could say, I'm going to put you on for longevity hacks.

What would you have that person do? Money's not an object. Go back to my jar. Yeah. Go back to my big rocks. Listen, if you want to live long, well, you have to move, not just from a strength standpoint, not just from a movement standpoint. So I'm my training is as an exercise physiologist and I'm very in tune with heart rate work.

Listen, every workout I've done for roughly the last 30 years, I have a record of what my heart rate was during that exercise. I worked for a company called Polar. All of a sudden, I was introduced to the value of a heart rate monitor, a continuous heart rate monitor, and it's incredible. But when you're looking at heart rate, when you're looking at training, we break training into five zones, with the top of the third zone being that what we call anaerobic aerobic threshold.

And so if when I'm training my athletes, we spend probably 60 % of our time just below the threshold of zone three in between below going into zone four. That's where you get a lot of great development from an athletic standpoint. But from a longevity standpoint and mitochondrial development, there is an incredible amount of value that comes from exercising in zone two.

Freddie Kimmel and Don Moxley (41:39.605)
So one of the great things that we learned with longevity, you don't have to cross fit and lay there in a puddle of sweat and bury yourself every time you work out. From a longevity standpoint, time spent in zone two is valuable. Walking time, cycling time, swimming time, this, but you need to raise the heart rate for a period of time and that's going to have a mitochondrial benefit. Number one. Number two, you have to pick up something heavy occasionally.

Okay, you have to engage in strength work for your hips and legs. I'll tell you a story that I really like. My wife teaches a Zumba class and it's all it's all a Zumba for 70 year olds, 60 year olds. And she had a gal in her class, her name's Mary and Mary had just retired from teaching. She was 62, 63. And if you train in my house, I have a great gym on my house and this is where everybody was coming. You do squats.

Okay, it's a movement that is universal and it's in everything I do. And Mary was grousing about doing squats one day and I said, damn it, Mary. I said, you just retired. I said, you're just entering your third third. And I said, you know what's gonna define the end of the best part of your third third? I said, it's independence. It's your ability to be independent. And that's going to be defined by your ability to sit down, defecate, clean yourself,

and walk away without assistance. When you can't do that anymore, you lose independence. The reason I squat and the reason you need to do that movement is because that's critical to long life. Okay? So you have to pick up something heavy occasionally and you need to do walking multiple times a day. You don't have to bury yourself. So exercise is critical. You cannot ignore it.

You have to pay attention to where your food's coming from. This is one of my big challenges. I love crappy food. I love junk food. Okay. It hits every receptor. It gives me pleasure. Okay. Give me your, like your awful junk food. Give me the worst. There is a McDonald's next to my hotel and I've gone twice and I don't normally eat that. I normally keep my environment pretty tight and that if I don't keep it tight, I'm eating crappy food. So we've got to pay attention when you have to be aware. And it's a challenge. Listen,

Freddie Kimmel and Don Moxley (44:05.185)
When you learn to track sleep, tracking sleep, you learn a lot. So if you don't have a sleep tracker in your life, you know, they're now very approachable. They're now very affordable, starting to pay attention to how sleep works. Sleep is important. You know, our culture was built on, I don't need to sleep. Bullshit. You have to sleep. Work that we did with the military. What was so funny, we're doing some work with the military when I was at Ohio State and they were, they're giving me an example. So they had these sleep deprived elite soldiers.

that were evaluating themselves doing an operation. And then they had well, they had well slept, well rested peers observing them. Well, the poor sleep group thought they did a great job. They reported the more they nailed it. The group that had that had was well rested, looked at him and said, you're, you're out of it. You, there's no, you, you, did a really bad job and you don't even recognize that we don't have to, you have to sleep well. And then again, that fourth big light is

critical when we start to look at light. Listen, there is so much value to getting in the sun and and you know, we were so afraid of the sun right now and rightly so you have to be careful. You don't want to burn your skin, but you need to get light and you know if you need to go to red light in order to facilitate that that's a good hack. The near infrared and the infrared lights are good. The big rocks in the jar. Freddy is where I go back to but remember the jar is your purpose.

Take a step back, figure out what, take a breath, figure out what your purpose in life is, what you wake up for. And that will help you align the jar. Yeah. That's beautiful. Beautiful information. It's actionable stuff. It's easy stuff. You know, those are easy principles. I know it. The environment is hard. have our, the environment that we live in has again,

There's a freaking McDonald's next to my hotel. And if I'm hungry, there's not a restaurant in this hotel. It's really hard for me to get past that McDonald's and make a good food decision. that's an invite. Listen, it takes willpower to do it. But we all again, we understand we understand that of cognitive and sati and what happens there. But environment is hard. We don't have to climb anymore. So your iliopsoas is a muscle that lifts your femur above 90 degrees in your hip.

Freddie Kimmel and Don Moxley (46:28.915)
It also crosses your sciatic nerve twice. Once when it comes out of your spine and once when it goes into the femur. If you're not climbing on something, if you're not picking that knee up and that iliopsoas starts to get aggravated and spasming, you're going to have back problems. Okay. And really all you have to do to solve this is climb, flex that knee above 90 degrees. Now we have exercise, we have hacks that we do it with, but our environment is incorporating an incredible amount

of anti-stress that you have to recognize. We have a TV in our room after dark. We have light that really throw off our circadian rhythm on the light side and mess up the sleep. Recognize the impact of the environment on your DNA and then make choices. The choices can be clear, but the power of the environment can be difficult to overcome and you have to just keep working on. It's a fight.

It's a fight, it's one worth doing, especially if that purpose is so strong. Don, I'm going to give people a just this, cause this is fun. You know, we're doing this interview and, but what people can do, and this is the first time we'll announce this is you can come meet Don Moxley and you can come meet Freddie Kimmel from the beautifully broken podcast. We're going to both be at a two day event in Miami called the biohacking Congress. That's October 16th through the 17th.

And I actually have a really incredible code here. You can get 50 % off all tickets with the promo code HACKT50. That's all caps, HACKT50. And join us in Miami. There's an incredible, incredible list of speakers. There's only over 25 speakers and 20 health companies and exhibition spaces. And you can get on a lot of this tech. You can try these supplements.

You can get face to face with some of these people that are preaching longevity and wellness and increasing your vibration. And there is nothing like learning in person in my experience. So I just want to make that invite to everybody. And Don is going to be there so you can get us both in the same place, both in the same geographic location. And that event is closely approaching. So I would jump on that if you're inspired. Don.

Freddie Kimmel and Don Moxley (48:42.697)
I want to end the podcast with again, being respectful of our hour, the beautifully broken podcast is putting the broken pieces back together. In your words, what does it mean to be beautifully broken? Well, listen, we all have challenges and we make mistakes, but your ability to learn from your mistakes is your superpower. That's the ability to really step up and

There's a concept in psychology that's called flow, the ultimate experience. And I love flow. love studying flow. I teach flow. And you learn when you're on the edges, when you're on your personal edge, when you're pushing it. And when we're working with athletes, this is a place that we live in, but it's a place that I like to go to. So listen, when you go to the edge, you break and that's okay. Be willing to take yourself there so that you can

experience flow so that you can learn and you can move and you can be a better version of yourself. Beautiful. Excellent. Excellent answer. I'm so excited to meet in person Don and share some more quality information and share a stage and talk about technology and wellness and all these great things that are offered to us. Again, for me, the goal is to be to mention

pulse electromagnetic fields, red light therapy, spermadine and not have it be a head turner at the Thanksgiving table. This is just normal conversation because listen, the world needs your help. It's struggling. need you at your very best. So be beautiful, stay beautiful. This is a beautifully broken podcast over and out. Thank you so much. Thank you for being here, Don. It was my honor. Namaste. My pleasure. Thank you.

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Freddie Kimmel and Don Moxley (50:55.219)
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Freddie Kimmel and Don Moxley (52:43.157)
My friends, you made it to the end of the podcast and here we are in season three. I think our relationship is developing into something really special. So there are two ways to support this show. The first is by joining my membership program at buymeacoffee.com forward slash freddy set go. Here you'll get early access to all the podcasts, bonus episodes, video clips,

Discounted coaching and free webinars with thought leaders in the wellness and transformational technology industry. It's a chance to take your listening experience and put it into action. The second way is to support the podcast through freddysetgo.com and download the beautifully broken buyer's guide. This is my new ebook, which is a collection of transformational technology supplements and courses that have worked for me, my clients and my family.

These are things that I found to be incredibly helpful in my healing journey and I put them all in one book. Most of them, most of them offer significant discounts just by clicking the link or using the discount code. And please know they don't cost you anything extra. And at the same time, they support the podcast through affiliations. My heart thanks you for tuning in. I'm so glad you're here with us. If you've enjoyed today's show, head over to Apple podcasts and leave a five-star review.

And if you want to connect with me directly, I'm on Instagram at freddysetgo or buymeacoffee.com forward slash freddysetgo. Last message from my vast team of lawyers that I pay a lot of money for. The information on this podcast is for educational purposes only. By listening, you agree not to use the information found here as medical advice to treat any medical condition in yourself, your family members or others. Always consult your own physician for any medical issues that you may be having challenges with. That's it for today. Our closing, the world is changing. We need you at your very best. So take the steps today to always be upgrading. Remember, while life is pain, putting the fractured pieces back together is a beautiful process. I love ya. I'm your host, Freddie Kimmel. Namaste.